Theranos debuts new blood-testing device; Google and GlaxoSmithKline team up on bioelectronics; and United States has first domestic Zika transmissions.
International cooperation is needed to stop developed nations simply offloading defunct electronics on developing countries, argue Zhaohua Wang, Bin Zhang and Dabo Guan.
Josie Glausiusz relishes Alison Gopnik's study on how child-rearing demands the embrace of messy realities.
Review of The Gardener and the Carpenter: What the New Science of Child Development Tells Us About the Relationship Between Parents and Children Alison Gopnik
Sequencing data from two large-scale studies show that most of the genetic variation influencing the risk of type 2 diabetes involves common alleles and is found in regions previously identified by genome-wide association studies, clarifying the genetic architecture of this disease.
Monoclonal antibodies isolated from patients with dengue virus infection also bind to the Zika virus E protein and neutralize both Zika and dengue virus infection; the structures of two of these antibodies in complex with the Zika virus envelope protein define the binding determinants of the epitope and identify the structural basis of antibody cross neutralization.
High-resolution near-infrared observations of the Occator bright areas on the dwarf planet Ceres suggest that the bright material is mostly made up of endogenous sodium carbonate.
A device consisting of a metallic island connected to electrodes via tunable semiconductor-based conduction channels is used to explore the evolution of charge quantization in the presence of quantum fluctuations; the measurements reveal a robust scaling of charge quantization as the square root of the residual electron reflection probability across a quantum channel, consistent with theoretical predictions.
A small programmable quantum computer is demonstrated that uses five trapped ions as qubits; the computer is reconfigurable and different algorithms can be compiled without changing the hardware.
Moving mechanical interfaces need to be lubricated to ensure long life and easy slippage; here, a new type of coating is described—comprising nitrides of either molybdenum or vanadium, together with a copper or nickel catalyst—that generates protective tribofilms from lubricating oils.
Satellite records show that the global pattern of cloud changes between the 1980s and the 2000s are similar to the patterns predicted by models of climate with recent external radiative forcing, and that the primary drivers of the cloud changes appear to be increasing greenhouse gas concentrations and a recovery from volcanic radiative cooling.
A novel rhythmogenic brainstem network was discovered in mice that is necessary and sufficient for generating postinspiration, a breathing phase also used for swallowing, coughing and vocalization.
Clinically relevant bacteria have been engineered to lyse synchronously at a threshold population density and release genetically encoded therapeutics; treatment of mice with these bacteria slowed the growth of tumours.
Atherosclerotic lesions in mice and humans switch on a ‘don’t eat me’ signal—expression of CD47—that prevents effective removal of diseased tissue; anti-CD47 antibody therapy can normalize this defective efferocytosis, with beneficial results in several mouse models of atherosclerosis.
Analyses of tumour samples and tumour-infiltrating lymphocytes from two patients with melanoma who were treated with adoptive T-cell therapy provide evidence for tumour escape by loss and downregulation of immunogenic antigens.
The initiation protein eIF3d serves as an alternative cap-recognition factor for a subclass of mRNAs, such as c-Jun; the high-resolution structure of the eIF3d cap-binding domain can be modelled onto the cap structure, defining interactions that are needed for translation of these mRNAs.
A cryo-electron microscopy structure of the DNA damage repair protein 53BP1 bound to a nucleosome illuminates the way 53BP1 recognizes two types of histone modifications (a methyl group and a ubiquitin moiety), and provides insight into the highly specified recognition and recruitment of 53BP1 to modified chromatin.
An engineered G protein is used to bind to and stabilize the active conformation of the adenosine A2Areceptor, enabling the acquisition of an X-ray crystal structure of this GPCR in an active state.
The cryo-electron microscopy structure of the homomeric GluA2 AMPA receptor in the presence of TARP γ2 subunits is reported, which reveals that TARPs are arranged around the ion channel domain and underneath the ligand-binding domains, poised to modulate receptor activity.
