Blood Brothers is the story of three close friends, Fung, Kang, and his little brother Hu. They begin the story as poor fishermen from Zhujiajiao, a small village on the outskirts of Shanghai. They are young and trapped by unfortunate circumstances; they decide to move to Shanghai in search of whatever opportunities the big city may have in store for them.
Once in Shanghai, they are tempted by riches they once could only imagine, but they never expected to become involved with the criminal underworld. They are quickly drawn into the vicious and seductive life provided by the most infamous nightclub in Shanghai, the Paradise Club, a place where the dance stage sparkles with beautiful women such as Lulu, the resident songstress and object of every man's desire. Behind the bright lights, a stream of blood flows deep and wide as Boss Hong, owner of the Paradise Club and a powerful figure in the crime world of Shanghai, discovers that Mark, his right-hand man, is having an affair with Lulu. All the while, both his enemies and his allies are plotting to wrestle control of local gangs away from him.
As the three brothers rise to power, Fung has to make a choice between this life of crime and unrequited love, or a return to the man he once was. Hu has been struggling with his own weakness and reconcile himself to the dangers of his new life in Shanghai while Kang, blinded by a lust for power, pursues his own ambitions at any cost.
By the end, lives will be lost, though redemption may still be within reach.