WHAT IS VITILIGO?
Vitiligo
is a disorder in which white patches of skin appear on
different
parts of the body. This happens because the cells that make pigment
(color)
in the skin are destroyed. These cells are called melanocytes. Vitiligo can
also affect the mucous membranes (such as the tissue inside the mouth and nose)
and the eye.
WHAT CAUSES VITILIGO?
Vitiligo occurs when
melanin-forming cells (melanocytes) die or stop producing melanin — the pigment
that gives your skin, hair and eyes color. The involved patches of skin become
lighter or white. Doctors don't know why the cells fail or die. Therefore,
the cause is not clearly known.
It may be related to:
·
A disorder in which your
immune system attacks and destroys the melanocytes in the skin
·
Family history (heredity)
·
A trigger event, such as
sunburn, stress or exposure to industrial chemicals
WHO IS AFFECTED BY VITILIGO?
Many people develop it in their twenties, but it can occur
at any age. The disorder
affects all races and both sexes equally, however, it is
more noticeable in people
with dark skin. People with certain autoimmune diseases
(such as hyperthyroidism) are more likely to get vitiligo than people who don't
have any autoimmune diseases.
Scientists do not know why vitiligo is connected with these
diseases. However,
most people with vitiligo have no other autoimmune disease.
Vitiligo may also run in families. Children whose parents have the disorder are
more likely to develop vitiligo. However, most children will not get vitiligo
even if a parent has it.
WHAT ARE THE SYMPTOMS OF VITILIGO?
White patches on the skin are the main sign of vitiligo.
These patches are more
common in areas where the skin is exposed to the sun. The
patches may be on the
hands, feet, arms, face, and lips. Other common areas for
white patches are:
The armpits and groin (where the leg meets the body)
Around the mouth
Eyes
Nostrils
Navel
Genitals
Rectal areas
People with vitiligo often have hair that turns gray early.
Those with dark skin may notice a loss of color inside their mouths.
WILL THE WHITE PATCHES SPREAD?
There is no way to tell if vitiligo will spread. For some
people, the white patches do not spread. But often the white patches will
spread to other areas of the body. For some people, vitiligo spreads slowly,
over many years. For other people, spreading occurs quickly. Some people have
reported more white patches after physical or emotional stress.
COMPLICATIONS
People with
vitiligo may be at increased risk of:
·
Social or psychological
distress
·
Sunburn and skin cancer
·
Eye problems, such as
inflammation of the iris (iritis)
·
Hearing loss
PSEUDOCATALASE PC-KUS TREATMENT
Pseudocatalase PC-KUS
has recently become a gold standard for patients suffering from vitiligo.
Pseudocatalase improves the appearance by restoring the pigmentation in the
affected areas. Though it can take 2-3 months to see results, it drastically
improves the quality of life and apperarance. Today with pseudocatalase,
vitiligo is a treatable condition. That’s is a breakthrough, considering the
recent hopeful treatment options.
Dr. Karin U.
Schallreuter and her colleagues, a professor of clinical and experimental
dermatology at the University of Bradford in West Yorkshire, England, created
pseudocatalase PC-KUS. The studies were conducted to apply PSEUDOCATALASE CREAM TWICE DAILY and EXPOSE AREA OF TREATMENT TO THE SUN APPROXIMATELY 15 MINUTES TWICE A
WEEK or to a short-term narrow-band of ultraviolet B (UVB) phototherapy.
It was shown to lower
levels of hydrogen peroxide (H2O2) on the skin, as well as improve defense by
supplementing catalase. Catalase, through activation by UV light, will break
down H2O2 to oxygen and water, instead of accumulation of H2O2 that
consequently affected pigmentation of the skin.
YOUR ORDER IS 12 GRAMS OF PSEUDOCATALASE PC-KUS POWDERS, MIXING INSTRUCTIONS AND DIRECTION OF USE.
Pseudocatalase Mixing Instructions
GETTING SET UP:
1. Assemble the following:
A. Packet A
B. Packet B
C. Packet C
D.
Distilled Water or Purified Water
E. Any Cream or Lotion (480Grams or 480ML)
STEPS FOR MIXING CREAM, LOTION, OR WITH WATER:
1.
Mix PACKET A with small amount of cream or
lotion approximately 50
grams or ML. It may slightly liquefy but that is normal.
2.
After properly mixing, mix it with the remaining
cream or lotion.
3.
In a separate small cup pour PACKET B into 14.5
ML of Distilled or Purified Water.
4.
Add PACKET C into step 3 and mix, allow mixture
to fizzle until evolution of gas has ceased.
5.
Add Step 4 with Step 2 and mix well.
NOTE: IF YOU DESIRE A LIQUID SOLUTION, MAY SUBSTITUTE CREAM
OR LOTION FOR DISTILLED WATER.
DIRECTIONS:
1.
Apply to area twice daily
2. Expose area to sun for approximately 20 minutes. Sun exposure (or UVB light) should be 40-60 min after applying cream twice weekly.
THANK YOU FOR YOUR PURCHASE, IF YOU DO NOT DESIRE TO MIX, WE PROVIDE IT ALREADY MIXED IN OTHER LISTING.
REFERENCED STUDIES
Treatment of vitiligo with a topical
application of pseudocatalase and calcium in combination with short-term UVB
exposure: a case study on 33 patients.
Schallreuter KU1, Wood JM, Lemke KR, Levenig C.
·
1Department of Dermatology, University of Hamburg, Germany.
Abstract
Thirty-three
patients with the depigmentation disorder vitiligo were successfully treated
with a new topical application of pseudocatalase, calcium and short-term UVB
light exposure. First repigmentation occurred in the majority of cases after
2-4 months. Complete repigmentation on the face and dorsum of the hands
appeared in 90% of the group. In all patients, active depigmentation was
arrested. None of them developed new lesions during treatment. No recurrence of
the disease was observed during a 2-year follow-up. The rationale for this
pilot study originated from a recent understanding of vitiligo at the molecular
level. The involved epidermis produces hydrogen peroxide due to defective
tetrahydrobiopterin recycling and increased monoamine oxidase A activity,
whereupon catalase is inactivated. In addition, calcium homeostasis is
perturbed in the affected skin. The substitution for insufficient catalase by a
pseudocatalase together with calcium and UVB exposure lead to effective
repigmentation.
Pseudocatalase
and Vitiligo
Mark
V. Dahl, MD reviewing Schallreuter KU et al. Int
J Dermatol 2008 Jul.
Two thirds of children
treated with pseudocatalase PC-KUS achieved 75% improvement or better in their
vitiligo.
Hydrogen
peroxide–mediated lipid peroxidation may damage epidermal cells, causing
vitiligo. In cultured melanocytes and keratinocytes, vacuolization caused by
peroxidation can be prevented by catalase, which breaks down peroxides, and by
“pseudocatalase” (PC-KUS), a complex of bis-Mn III [EDTA]2 [HCO3-]2, which can be
applied to skin and activated by narrow-band ultraviolet-B (NB-UVB) radiation.
In this
study, 71 children with vitiligo were treated with PC-KUS that was activated by
UVB daily. The PC-KUS topical preparation was applied twice daily to the entire
body. NB-UVB was administered once daily for 14 days and then twice weekly for
4 weeks. Thereafter, PC-KUS was applied once daily, and up to 1 hour of sun
exposure daily was allowed. Ten children received NB-UVB alone (monotherapy).
Assessment was made after 12 months.
Progression
of vitiligo was halted in 70 of the 71 children treated with NB-UVB–activated
PC-KUS; 66 experienced better than 75% repigmentation of the face and neck, and
39% had complete repigmentation. Better than 75% repigmentation also occurred
in 48 of 61 treated children with vitiligo on the trunk and in 40 of 55
children with vitiligo on the extremities. Only five children with vitiligo on
the hands had 75% repigmentation. Success was independent of Fitzpatrick skin
type and disease duration. The 10 children treated with monotherapy did not
experience much if any repigmentation, and their disease progression was not
halted.
- See more at:
http://www.jwatch.org/jd200808150000002/2008/08/15/pseudocatalase-and-vitiligo#sthash.7LD1xyub.dpuf