Each issue of Grimm Fairy Tales
has two parts: a frame story and a fairy tale. The frame story revolves
around Dr. Sela Mathers, a Professor of Literature with the
supernatural ability to help people to avoid bad life decisions by
subjecting them to visions, in which they see themselves as the
protagonists of allegorical fairy tales. As the series progresses, she
struggles with the fact that several people ignore her lessons and ruin
their lives anyway, and begins using her ability to dispense justice
instead. Sela's nemesis is Belinda, who has the same ability as Sela but
uses it for evil.
The other portion of the story is a twisted version of a classic
fairy tale. The fairy tales are often violent and usually end in
depressing ways, warning the readers to change their lives or suffer a
similar (or sometimes worse) fate.
It is later revealed that Belinda is working for the Dark One, a
Satan-like demon who is seeking to conquer not only Earth but four other
worlds which the fairy tales come from. The worlds include Wonderland,
Oz, Neverland, and Myst. The series gradually begins to revolve around
Sela herself, as she discovers that she has become a major player in an
ancient war between the Dark Horde, led by the Dark One and his allies,
and the Guardians, leaders of the worlds the Dark One seeks to conquer.
Already Wonderland and Neverland have fallen and are now ruled by the
Dark One's allies, the monstrous Jabberwocky and the soul-devouring
immortal Pan, respectively.
After Volume 15 concluded, a new Zenescope comic event, "The Age of Darkness", began. It spans in every comic related to the Grimm Fairy Tales series. There are major tie-ins and things especially related to major worlds in Grimm Fairy Tales. These worlds are Oz, Myst, Neverland, Wonderland, and Earth. The event happened in 2013–14 heading up to the 100th issue of Grimm Fairy Tales.
After the milestone issue, issues #101–125 are the "Arcane Acres" storyline.