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Advances in Industrial Mixing

by Suzanne M. Kresta, Arthur W. Etchells, III, David S. Dickey, Victor A. Atiemo-Obeng, North American Mixing Forum

Advances in Industrial Mixing is a companion volume and update to the Handbook of Industrial Mixing. The second volume fills in gaps for a number of industries that were not covered in the first edition. Significant changes in five of the fundamental areas are covered in entirely updated or new chapters.

FORMAT
Hardcover
LANGUAGE
English
CONDITION
Brand New


Publisher Description

Advances in Industrial Mixing is a companion volume and update to the Handbook of Industrial Mixing. The second volume fills in gaps for a number of industries that were not covered in the first edition. Significant changes in five of the fundamental areas are covered in entirely updated or new chapters. The original text is provided as a searchable pdf file on the accompanying USB.

  • This book explains industrial mixers and mixing problems clearly and concisely.
  • Gives practical insights by the top professionals in the field, combining industrial design standards with fundamental insight.
  • Details applications in 14 key industries. Six of these are new since the first edition.
  • Provides the professional with information he/she did not receive in school.
  • Five completely rewritten chapters on mixing fundamentals where significant advances have happened since the first edition and seven concise update chapters which summarize critical technical information.

Back Cover

Includes 5 completely rewritten and updated fundamentals chapters and specialized chapters for 6 new industries - all by leading professionals in the field While process objectives are critical to the successful manufacturing of a product, if the mixing scale-up fails to produce the required results, the costs of manufacturing can increase significantly. Although there are several industrial operations in which mixing requirements are readily scaled up from established correlations, many operations require a more thorough evaluation. This comprehensive handbook provides practical insights from the leading professionals in the field and presents the latest methods for recognizing these more complex operations. The Advances Volume is a companion to the Handbook of Industrial Mixing. It reworks areas that have seen significant progress since the first edition and includes: Brand new chapters for 6 areas of industrial application: pharmaceutical validation, crystallization, water treatment, commissioning of mixing equipment, and safety Additional sections or examples for 5 chapters from the first edition including: magnetic drives, micromixers, vessel head volume calculations, additional information on heat transfer, and application of the Bourne protocol to reactor design Concise but critical technical updates for mixing in pipelines, turbulence, and CFD 5 completely new fundamentals chapters covering: mean age distrbution, rheology and complex fluids, flow patterns, viscous mixing, solid-liquid mixing A full technical definition of mixing The advances volume will be a welcome addition to the Handbook of Industrial Mixing for the practicing engineer who needs to both identify and solve mixing problems. This book also provides concise discussions on theoretical background and uses many illustrative examples when covering applications. It includes a DVD with a searchable pdf copy of the first edition, twenty tutorials on mixing, and a collection of video clips and animations of mixing processes, many of which are new for this edition. Suzanne M. Kresta is a professor in the Department of Chemical and Materials Engineering at the University of Alberta. Arthur W. Etchells III is a retired DuPont Fellow with over forty years consulting in industrial mixing. David S. Dickey is a consultant specializing in mixing processes and equipment with MixTech, Inc. He has more than forty years experience with mixing processes and equipment. Victor Atiemo-Obeng is retired from The Dow Chemical Company where he worked as a scientist in the Engineering Science and Market Development department. The North American Mixing Forum provides an opportunity for dialogue about mixing problems in a wide range of industrial applications.

Flap

Includes 5 completely rewritten and updated fundamentals chapters and specialized chapters for 6 new industries - all by leading professionals in the field While process objectives are critical to the successful manufacturing of a product, if the mixing scale-up fails to produce the required results, the costs of manufacturing can increase significantly. Although there are several industrial operations in which mixing requirements are readily scaled up from established correlations, many operations require a more thorough evaluation. This comprehensive handbook provides practical insights from the leading professionals in the field and presents the latest methods for recognizing these more complex operations. The Advances Volume is a companion to the Handbook of Industrial Mixing. It reworks areas that have seen significant progress since the first edition and includes: Brand new chapters for 6 areas of industrial application: pharmaceutical validation, crystallization, water treatment, commissioning of mixing equipment, and safety Additional sections or examples for 5 chapters from the first edition including: magnetic drives, micromixers, vessel head volume calculations, additional information on heat transfer, and application of the Bourne protocol to reactor design Concise but critical technical updates for mixing in pipelines, turbulence, and CFD 5 completely new fundamentals chapters covering: mean age distrbution, rheology and complex fluids, flow patterns, viscous mixing, solid-liquid mixing A full technical definition of mixing The advances volume will be a welcome addition to the Handbook of Industrial Mixing for the practicing engineer who needs to both identify and solve mixing problems. This book also provides concise discussions on theoretical background and uses many illustrative examples when covering applications. It includes a DVD with a searchable pdf copy of the first edition, twenty tutorials on mixing, and a collection of video clips and animations of mixing processes, many of which are new for this edition. Suzanne M. Kresta is a professor in the Department of Chemical and Materials Engineering at the University of Alberta. Arthur W. Etchells III is a retired DuPont Fellow with over forty years consulting in industrial mixing. David S. Dickey is a consultant specializing in mixing processes and equipment with MixTech, Inc. He has more than forty years experience with mixing processes and equipment. Victor Atiemo-Obeng is retired from The Dow Chemical Company where he worked as a scientist in the Engineering Science and Market Development department. The North American Mixing Forum provides an opportunity for dialogue about mixing problems in a wide range of industrial applications.

Author Biography

Suzanne M. Kresta is a professor in the Department of Chemical and Materials Engineering at the University of Alberta.

Arthur W. Etchells III is a retired DuPont Fellow with over forty years consulting in industrial mixing.

David S. Dickey is a consultant specializing in mixing processes and equipment with MixTech, Inc. He has more than forty years experience with mixing processes and equipment.

Victor Atiemo-Obeng is retired from The Dow Chemical Company where he worked as a scientist in the Engineering Science and Market Development department.

The North American Mixing Forum provides an opportunity for dialogue about mixing problems in a wide range of industrial applications.

Table of Contents

Contributors List xxxix Editors' Introduction xliii Contents of the DVD, Including Instructional Videos lvii A Technical Definition of Mixing 1
Joelle Aubin and Suzanne M. Kresta Range of Industrial Mixing Applications 2 Three Dimensions of Segregation: A Technical Definition of Mixing 3 Identifying Mixing Problems: Defining the Critical Scales and Process Objectives 5 Notation 9 References 9 1a Residence Time Distributions 11
E. Bruce Nauman 1a-1 Introduction 12 1a-2 Measurements and Distribution Functions 1a-3 Residence Time Models of Flow Systems 1a-4 Uses of Residence Time Distributions 1a-5 Extensions of Residence Time Theory Nomenclature References 1b Mean Age Theory for Quantitative Mixing Analysis 15
Minye Liu 1b-1 Introduction 15 1b-2 Age and Time in a Flow System 16 1b-3 Governing Equations of Mean Age and Higher Moments 17 1b-4 Computation of Mean Age 20 1b-5 Relations of Mean Age and Residence Time Distribution 25 1b-6 Variances and the Degree of Mixing 27 1b-7 Mean Age and Concentration in a CFSTR 31 1b-8 Probability Distribution Function of Mean Age 34 1b-9 Future Development of Mean Age Theory 39 Nomenclature 39 Greek Letters 40 References 41 2a Turbulence in Mixing Applications 43
Suzanne M. Kresta and Robert S. Brodkey 2a-1 Introduction 44 2a-2 Background 2a-3 Classical Measures of Turbulence 2a-4 Dynamics and Averages: Reducing the Dimensionality of the Problem 2a-5 Modeling the Turbulent Transport 2a-6 What Have We Learned? Nomenclature References 2b Update to Turbulence in Mixing Applications 47
Marcio B. Machado and Suzanne M. Kresta 2b-1 Introduction 47 2b-2 The Velocity Field and Turbulence 48 2b-3 Spectrum of Turbulent Length Scales: Injection of Scalar (Either Reagent or Additive) and the Macro-, Meso-, and Microscales of Mixing 56 2b-4 Turbulence and Mixing of Solids, Liquids, and Gases 65 2b-5 Specifying Mixing Requirements for a Process 66 2b-6 Conclusions 78 Notation 78 Roman Characters 78 Greek Characters 79 References 80 3a Laminar Mixing: A Dynamical Systems Approach 85
Edit S. Szalai, Mario M. Alvarez, and Fernando J. Muzzio 3a-1 Introduction 86 3a-2 Background 3a-3 How to Evaluate Mixing Performance 3a-4 Physics of Chaotic Flows Applied to Laminar Mixing 3a-5 Applications to Physically Realizable Chaotic Flows 3a-6 Reactive Chaotic Flows 3a-7 Summary 3a-8 Conclusions Nomenclature References 3b Microstructure, Rheology, and Processing of Complex Fluids 87
Patrick T. Spicer and James F. Gilchrist 3b-1 Introduction 87 3b-2 Literature Analysis—Mixing of Complex Fluids 90 3b-3 Common Complex Fluid Rheology Classes and Their Effects 92 3b-4 Conclusions 110 Nomenclature 110 Greek Symbols 111 References 111 4 Experimental Methods Part A: Measuring Tools and Techniques for Mixing and Flow Visualization Studies 115
David A. R. Brown, Pip N. Jones, and John C. Middleton 4-1 Introduction 117 4-2 Mixing Laboratory 4-3 Power Draw or Torque Measurement 4-4 Single-Phase Blending 4-5 Solid–Liquid Mixing 4-6 Liquid–Liquid Dispersion 4-7 Gas–Liquid Mixing 4-8 Other Techniques Part B: Fundamental Flow Measurement 4-9 Scope of Fundamental Flow Measurement Techniques 4-10 Laser Doppler Anemometry 4-11 Phase Doppler Anemometry 4-12 Particle Image Velocimetry Nomenclature References 5a Computational Fluid Mixing 119
Elizabeth Marden Marshall and Andre Bakker 5a-1 Introduction 120 5a-2 Computational Fluid Dynamics 5a-3 Numerical Methods 5a-4 Stirred Tank Modeling Using Experimental Data 5a-5 Stirred Tank Modeling Using the Actual Impeller Geometry 5a-6 Evaluating Mixing from Flow Field Results 5a-7 Applications 5a-8 Closing Remarks Acknowledgments Nomenclature References 5b CFD Modeling of Stirred Tank Reactors 123
Minye Liu 5b-1 Numerical Issues 123 5b-2 Turbulence Models 131 5b-3 Quantitative Predictions 137 5b-4 Modeling Other Physics 142 Nomenclature 144 Greek Letters 144 References 145 6a Mechanically Stirred Vessels 149
Ramesh R. Hemrajani and Gary B. Tatterson 6a-1 Introduction 150 6a-2 Key Design Parameters 6a-3 Flow Characteristics 6a-4 Scale-up 6a-5 Performance Characteristics and Ranges of Application 6a-6 Laminar Mixing in Mechanically Stirred Vessels Nomenclature References 6b Flow Patterns and Mixing 153
Suzanne M. Kresta and David S. Dickey 6b-1 Introduction 153 6b-2 Circulation Patterns 154 6b-3 Coupling the Velocity Field with Applications 178 Nomenclature 185 Greek Symbols 185 References 186 6c Vessel Heads: Depths, Volumes, and Areas 189
David S. Dickey, Daniel R. Crookston, and Reid B. Crookston 6c-1 Head Depth 190 6c-2 Head Volume 193 6c-3 Head Area 194 6c-4 Dimensionless Coefficients for Torispherical Heads 195 6c-5 Calculations for Conical Bottoms 197 6c-6 Other Types of Bottoms 199 Nomenclature 199 Dimensional Variables and Parameters 199 Dimensionless Variables and Parameters 199 Dimensionless Greek Symbols 200 References 200 7a Mixing in Pipelines 201
Arthur W. Etchells III and Chris F. Meyer 7a-1 Introduction 202 7a-2 Fluid Dynamic Modes: Flow Regimes 7a-3 Overview of Pipeline Device Options by Flow Regime 7a-4 Applications 7a-5 Blending and Radial Mixing in Pipeline Flow 7a-6 Tee Mixers 7a-7 Static or Motionless Mixing Equipment 7a-8 Static Mixer Design Fundamentals 7a-9 Multiphase Flow in Motionless Mixers and Pipes 7a-10 Transitional Flow 7a-11 Motionless Mixers: Other Considerations 7a-12 In-line Mechanical Mixers 7a-13 Other Process Results 7a-14 Summary and Future Developments Acknowledgments Nomenclature References 7b Update to Mixing in Pipelines 205
Thomas A. Simpson, Michael K. Dawson, and Arthur W. Etchells III 7b-1 Introduction 205 7b-2 Use of CFD with Static Mixers 206 7b-3 Recent Developments in Single-Phase Blending 207 7b-4 Recent Developments in Multiphase Dispersions 222 7b-5 Mixing with Static Mixers When Solids are Present 229 Notation 232 Roman Characters 232 Greek Characters 233 Subscripts 233 References 235 7c Introduction to Micromixers 239
Joelle Aubin and Abraham D. Stroock 7c-1 Introduction 239 7c-2 Mixing and Transport Phenomena 240 7c-3 Micromixer Geometries and Fluid Contacting Mechanisms 241 7c-4 Characterization of Flow and Mixing 244 7c-5 Multiphase Mixing 245 7c-6 Commercial Equipment and Industrial Examples 247 7c-7 Evaluation of the Current and Future Applicability of Microreactors in Industry 250 Notation 251 Suggested Reading 251 References 251 8 Rotor–Stator Mixing Devices 255
Victor Atiemo-Obeng and Richard V. Calabrese 8-1 Introduction 256 8-2 Geometry and Design Configurations 8-3 Hydrodynamics of Rotor–Stator Mixers 8-5 Mechanical Design Considerations 8-6 Rotor–Stator Mixing Equipment Suppliers Nomenclature References 9a Blending of Miscible Liquids 259
Richard K. Grenville and Alvin W. Nienow 9a-1 Introduction 260 9a-2 Blending of Newtonian Fluids in the Turbulent and Transitional Regimes 9a-3 Blending of Non-Newtonian, Shear-Thinning Fluids in the Turbulent and Transitional Regimes 9a-4 Blending in the Laminar Regime 9a-5 Jet Mixing in Tanks Nomenclature References 9b Laminar Mixing Processes in Stirred Vessels 261
Philippe A. Tanguy, Louis Fradette, Gabriel Ascanio, and Ryuichi Yatomi 9b-1 Introduction 261 9b-2 Laminar Mixing Background 263 9b-3 Rheologically Complex Fluids 266 9b-4 Heat Effects 268 9b-5 Laminar Mixing Equipment 269 9b-6 Key Design Parameters 274 9b-7 Power Number and Power Constant 276 9b-8 Experimental Techniques to Determine Blend Time 282 9b-9 Mixing Efficiency 285 9b-10 Characterization of the Mixing Flow Field 288 9b-11 Hydrodynamic Characterization of Laminar Blending 301 9b-12 Application of Chaos in Mixing 317 9b-13 Selecting an Appropriate Geometry for Generic Applications 328 9b-14 Heat and Mass Transfer in the Laminar Mixing 336 9b-15 Industrial Mixing Process Requirements 338 9b-16 Scale-up Rules in the Laminar Regime 340 9b-17 Mixer Troubleshooting and Engineering Calculations 342 9b-18 Concluding Remarks 347 Acknowledgments 348 References 348 10 Solid–Liquid Mixing 357
David A. R. Brown, Arthur W. Etchells III, with sections by Richard K. Grenville, Kevin J. Myers, N. Gul Ozcan-Taskin incorporating sections by Victor A. Atiemo-Obeng, Piero H. Armenante, and W. Roy Penney 10-1 Introduction and Scope 358 10-2 Solid and Liquid Physical Characteristics 364 10-3 Agitation of Sinking or Settling Solids 371 10-4 Incorporation and Dispersion of Floating Solids 416 10-5 Attrition and Particle Damage 425 10-6 Solids Suspension and Distribution Using Liquid Jets 430 10-7 Mass Transfer 431 10-8 Lab and Pilot-Scale Testing 440 Nomenclature 441 Dimensional Variables and Parameters 441 Dimensionless Parameters 442 Greek Symbols 443 References 443 11 Gas—Liquid Mixing in Turbulent Systems 451
John C. Middleton and John M. Smith 11-1 Introduction 452 11-2 Selection and Configuration of Gas–Liquid Equipment 11-3 Flow Patterns and Operating Regimes 11-4 Power 11-5 Gas Hold-up or Retained Gas Fraction 11-6 Gas–Liquid Mass Transfer 11-7 Bubble Size 11-8 Consequences of Scale-up Nomenclature References 12 Immiscible Liquid–Liquid Systems 457
Douglas E. Leng and Richard V. Calabrese 12-1 Introduction 459 12-2 Liquid–Liquid Dispersion 12-3 Drop Coalescence 12-4 Population Balances 12-5 More Concentrated Systems 12-6 Other Considerations 12-7 Equipment Selection for Liquid–Liquid Operations 12-8 Scale-up of Liquid–Liquid Systems 12-9 Industrial Applications Nomenclature References 13a Mixing and Chemical Reactions 465
Gary K. Patterson, Edward L. Paul, Suzanne M. Kresta, and Arthur W. Etchells III 13a-1 Introduction 466 13a-2 Principles of Reactor Design for Mixing-Sensitive Systems 13a-3 Mixing and Transport Effects in Heterogeneous Chemical Reactors 13a-4 Scale-up and Scale-down of Mixing-Sensitive Systems 13a-5 Simulation of Mixing and Chemical Reaction 13a-6 Conclusions Nomenclature References 13b Scale-up Using the Bourne Protocol: Reactive Crystallization and Mixing Example 479
Aaron Sarafinas and Cheryl I. Teich 13b-1 Example: Redesigning an Uncontrolled Precipitation to a Reactive Crystallization 479 Goal 479 Issue 479 References 489 14a Heat Transfer 491
W. Roy Penney and Victor A. Atiemo-Obeng 14a-1 Introduction 492 14a-2 Fundamentals 14a-3 Most Cost-Effective Heat Transfer Geometry 14a-4 Heat Transfer Coefficient Correlations 14a-5 Examples Nomenclature References 14b Heat Transfer in Stirred Tanks—Update 493
Jose Roberto Nunhez 14b-1 Introduction 493 14b-2 Consideration of Heat Transfer Surfaces used in Mixing Systems 496 14b-3 Heating and Cooling of Liquids 506 14b-4 Summary of Proposed Equations Used in Heat Transfer for Stirred Tanks 512 14b-5 Methodology for Design of Heating Mixing System 518 14b-6 Example 518 Acknowledgments 529 Nomenclature 529 Greek Symbols 531 References 531 15 Solids Mixing Part A: Fundamentals of Solids Mixing 533
Fernando J. Muzzio, Albert Alexander, Chris Goodridge, Elizabeth Shen, and Troy Shinbrot 15-1 Introduction 15-2 Characterization of Powder Mixtures 15-3 Theoretical Treatment of Granular Mixing 15-4 Batch Mixers and Mechanisms 15-6 Conclusions Part B: Mixing of Particulate Solids in the Process Industries 533
Konanur Manjunath, Shrikant Dhodapkar, and Karl Jacob 15-7 Introduction 15-8 Mixture Characterization and Sampling 15-9 Selection of Batch and Continuous Mixers 15-10 Fundamentals and Mechanics of Mixer Operation 15-11 Continuous Mixing of Solids 15-12 Scale-up and Testing of Mixers Nomenclature References 16 Mixing of Highly Viscous Fluids, Polymers, and Pastes 539
the late David B. Todd 16-1 Introduction 539 16-2 Viscous Mixing Fundamentals 16-3 Equipment for Viscous Mixing 16-4 Equipment Selection 16-5 Summary Nomenclature References 17 Mixing in the Fine Chemicals and Pharmaceutical Industries 541
Edward L. Paul (retired), Michael Midler, and Yongkui Sun 17-1 Introduction 542 17-2 General Considerations 17-3 Homogeneous Reactions 17-4 Heterogeneous Reactions 17-5 Mixing and Crystallization

References

18 Mixing in the Fermentation and Cell Culture Industries 543 Ashraf Amanullah and Barry C. Buckland, and Alvin W. Nienow 18-1 Introduction 544 18-2 Scale-up/Scale-down of Fermentation Processes 18-3 Polysaccharide Fermentations 18-4 Mycelial Fermentations 18-5 Escherichia coli Fermentations 18-6 Cell Culture 18-7 Plant Cell Cultures Nomenclature References 19 Fluid Mixing Technology in the Petroleum Industry 547
Ramesh R. Hemrajani 19-1 Introduction 548 19-2 Shear-Thickening Fluid for Oil Drilling Wells 19-3 Gas Treating for CO2 Reduction 19-4 Homogenization of Water in Crude Oil Transfer Lines 19-5 Sludge Control in Crude Oil Storage Tanks 19-6 Desalting 19-7 Alkylation 19-8 Other Applications Nomenclature References 20 Mixing in the Pulp and Paper Industry 551
the late Chad P.J. Bennington 20-1 Introduction 552 20-2 Selected Mixing Applications in Pulp and Paper Processes: Non fibrous Systems 20-3 Pulp Fiber Suspensions 20-4 Scales of Mixing in Pulp Suspensions 20-5 Macroscale Mixing/Pulp Blending Operations 20-6 Mixing in Pulp Bleaching Operations 20-7 Conclusions Nomenclature References 21a Mechanical Design of Mixing Equipment 555
David S. Dickey and Julian B. Fasano 21-1 Introduction 556 21-2 Mechanical Features and Components of Mixers 21.3 Motors 21.4 Speed Reducers 21.5 Shaft Seals 21.6 Shaft Design 21.7 Impeller Features and Design 21.8 Tanks and Mixer Supports 21.9 Wetted Materials of Construction Nomenclature References 21b Magnetic Drives for Mixers 559
David S. Dickey 22 Role of the Mixing Equipment Supplier 567
Ron Weetman 22-1 Introduction 568 22-2 Vendor Experience 22-3 Options 22-4 Testing 22-5 Mechanical Reliability 22-6 Service 22-7 Key Points References 23 Commissioning Mixing Equipment 569
David S. Dickey, Eric Janz, Todd Hutchinson, Thomas Dziekonski, Richard O. Kehn, and Kayla Preston and Jay Dinnison 23-1 Introduction 569 23-2 Commissioning Concepts 570 23-3 Instructions for Commissioning 572 23-4 Safety Instructions 573 23-5 Receiving the Equipment 575 23-6 Kinds of Storage 578 23-7 Installation 582 23-8 Lubrication 590 23-9 Wiring 594 23-10 Initial Operation 595 23-11 Troubleshooting 597 23-12 Maintenance 597 23-13 Commissioning Shaft Seals 597 23-14 Mechanical Checkout, Startup, and Troubleshooting of Agitator Equipment 609 23-15 Summary 639 Nomenclature 639 Greek Symbols 640 References 640 24 Mixing Safety 641
Gord Winkel and David S. Dickey 24-1 Introduction 641 24-2 The Practice of Risk Management 642 24-3 Summary Comments on Mixing Safety 661 References 663 25 Mixing Issues in Crystallization and Precipitation Operations 665
Alvin W. Nienow and Edward L. Paul 25-1 Introduction 665 25-2 Basic Crystallization Concepts 667 25-3 Impact of Mixing on Primary Heterogeneous Nucleation 673 25-4 Impact of Mixing on Secondary Nucleation 678 25-5 Impact of Mixing on Crystal Growth and Dissolution Rates 684 25-6 Selecting Operating Conditions to Optimize Crystal Suspension and Withdrawal 687 25-7 Damkoehler Number for Nucleation and Subsurface Feeding of Reactants 695 25-8 Stirred Vessel Crystallizers 700 25-9 Other Types of Equipment 704 25-10 Precipitation 706 25-11 Agglomeration and Oiling Out 712 25-12 Conclusions 714 Nomenclature 716 Greek Symbols 717 Subscripts 718 References 718 Appendices 722 26 Mixing in the Water and Wastewater Industry 729
Michael K. Dawson 26-1 Introduction 729 26-2 Mixing in Drinking Water Treatment 735 26-3 Mixing in Wastewater Treatment 758 26-4 Mixing in Sludge Treatment 765 26-5 Conclusions 775 Nomenclature 775 Greek Symbols 776 References 777 27 Mixing in the Food Industry 783
P. J. Cullen, Wesley Twombly, Robin Kay Connelly, and David S. Dickey 27-1 Introduction 783 27-2 Building or Reducing Texture Through Mixing 784 27-3 Role of Mixing in Food Treatment 796 27-4 Food Homogeneity 802 27-5 Advances in the Science of Food Mixing 803 27-6 Other Food Mixers 803 27-7 Typical Food Groups 818 Nomenclature 823 Greek Symbols 823 References 823 28 Mixing and Processes Validation in the Pharmaceutical Industry 827
Otute Akiti and Piero M. Armenante 28-1 Introduction 827 28-2 Validation in Pharmaceutical Industry 828 28-3 Pharmaceutical Processes and Role of Mixing in Pharmaceutical Production 836 28-4 Examples of Process Validation in Pharmaceutical Industry 852 28-5 Example of Process Validation for API Manufacturing: Manufacturing of EX123 API 852 28-6 Example of Process Validation for Drug Product Manufacturing: Manufacturing of EX123 Drug Product 864 Verification 884 Acknowledgment 885 References 885 Index 891

Review

"Advances in Industrial Mixing" is an updated version of the "Handbook of Industrial Mixing"
(1). The unchanged text of the "Handbook of Industrial Mixing" is provided electronically (on the accompanying DVD), and only the new or substantially revised contents are provided in the hard copy.....In summary, "Advances in Industrial Mixing" provides an expansion to the "Handbook of Industrial Mixing" (1), including new developments
in both experimental and numerical approaches and new methods developed based on more extensive data for assessing mixing quality. With regards to the issues raised in industry, a wide range of new materials are added in this volume, such as health and safety, and mixing in water, food and the pharmaceutical industry. (Johnson Matthey Technol. Rev., 2017, 61:4)

Long Description

Includes 5 completely rewritten and updated fundamentals chapters and specialized chapters for 6 new industries all by leading professionals in the field While process objectives are critical to the successful manufacturing of a product, if the mixing scale-up fails to produce the required results, the costs of manufacturing can increase significantly. Although there are several industrial operations in which mixing requirements are readily scaled up from established correlations, many operations require a more thorough evaluation. This comprehensive handbook provides practical insights from the leading professionals in the field and presents the latest methods for recognizing these more complex operations. The Advances Volume is a companion to the Handbook of Industrial Mixing. It reworks areas that have seen significant progress since the first edition and includes: Brand new chapters for 6 areas of industrial application: pharmaceutical validation, crystallization, water treatment, commissioning of mixing equipment, and safety Additional sections or examples for 5 chapters from the first edition including: magnetic drives, micromixers, vessel head volume calculations, additional information on heat transfer, and application of the Bourne protocol to reactor design Concise but critical technical updates for mixing in pipelines, turbulence, and CFD 5 completely new fundamentals chapters covering: mean age distrbution, rheology and complex fluids, flow patterns, viscous mixing, solid-liquid mixing A full technical definition of mixing The advances volume will be a welcome addition to the Handbook of Industrial Mixing for the practicing engineer who needs to both identify and solve mixing problems. This book also provides concise discussions on theoretical background and uses many illustrative examples when covering applications. It includes a DVD with a searchable pdf copy of the first edition, twenty tutorials on mixing, and a collection of video clips and animations of mixing processes, many of which are new for this edition. Suzanne M. Kresta is a professor in the Department of Chemical and Materials Engineering at the University of Alberta. Arthur W. Etchells III is a retired DuPont Fellow with over forty years consulting in industrial mixing. David S. Dickey is a consultant specializing in mixing processes and equipment with MixTech, Inc. He has more than forty years experience with mixing processes and equipment. Victor Atiemo-Obeng is retired from The Dow Chemical Company where he worked as a scientist in the Engineering Science and Market Development department. The North American Mixing Forum provides an opportunity for dialogue about mixing problems in a wide range of industrial applications.

Review Text

"Advances in Industrial Mixing" is an updated version of the "Handbook of Industrial Mixing" (1). The unchanged text of the "Handbook of Industrial Mixing" is provided electronically (on the accompanying DVD), and only the new or substantially revised contents are provided in the hard copy.....In summary, "Advances in Industrial Mixing" provides an expansion to the "Handbook of Industrial Mixing" (1), including new developments in both experimental and numerical approaches and new methods developed based on more extensive data for assessing mixing quality. With regards to the issues raised in industry, a wide range of new materials are added in this volume, such as health and safety, and mixing in water, food and the pharmaceutical industry. (Johnson Matthey Technol. Rev., 2017, 61:4)

Review Quote

"Advances in Industrial Mixing" is an updated version of the "Handbook of Industrial Mixing" (1). The unchanged text of the "Handbook of Industrial Mixing" is provided electronically (on the accompanying DVD), and only the new or substantially revised contents are provided in the hard copy.....In summary, "Advances in Industrial Mixing" provides an expansion to the "Handbook of Industrial Mixing" (1), including new developments in both experimental and numerical approaches and new methods developed based on more extensive data for assessing mixing quality. With regards to the issues raised in industry, a wide range of new materials are added in this volume, such as health and safety, and mixing in water, food and the pharmaceutical industry. (Johnson Matthey Technol. Rev., 2017, 61:4)

Details

ISBN0470523824
Short Title ADVANCES IN INDUSTRIAL MIXING
Language English
ISBN-10 0470523824
ISBN-13 9780470523827
Media Book
Format Hardcover
Subtitle A Companion to the Handbook of Industrial Mixing
Edition 1st
Edition Description Revised
Edited by Arthur W. Etchells
Country of Publication United States
UK Release Date 2015-12-22
AU Release Date 2015-11-09
NZ Release Date 2015-11-09
Author North American Mixing Forum
Publisher John Wiley & Sons Inc
Year 2015
Publication Date 2015-12-22
Imprint John Wiley & Sons Inc
Place of Publication New York
DEWEY 660.284292
Audience Professional & Vocational
US Release Date 2015-12-22
Pages 1040

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