Despite this 'chastity' connotation, Agnus Castus always enjoyed the reputation as a well respected woman's herb that was known to regulate the ups and downs of the monthly cycle. It appears that it does so by influencing the pituitary gland, which in turn regulates the reproductive hormones.

The German Commission E confirmed this historical use and classifies Agnus Castus as a safe herb to use in any conditions that are caused by hormonal imbalances, such as PMS, bloating, tender or painful breasts, moodiness, depression, headaches, acne etc as well as menopausal symptoms, such as hot flashes and night sweats.

Studies have also shown that women who have difficulties conceiving because of hormonal disturbances may benefit from the use of Agnus Castus.