Spermidine is the most abundant polyamine in the body[1], and is essential for tissue regeneration, cell growth and cell proliferation. Spermidine is also critical to the processes involved in controlling apoptosis, learning and memory, and binds to and stabilizes RNA and DNA, modulates enzyme functions, preserves and enhances mitochondrial metabolic function and respiration, and has anti-inflammatory properties and antioxidant functions[2,3,4,5,10].

Spermidine is also a natural inducer of autophagy[6], a cytoprotective self-digestive process that assists in removing and recycling damaged and potentially harmful cytoplasmic material that otherwise would accumulate during aging, and is key to health and longevity[7,10].

Spermidine is naturally found in foods such as green peas, chickpeas, cauliflower, broccoli, mushroom and mango in amounts ranging from 25 to 90 mg/kg. Amounts in cheddar cheese, soybean and wheat germ range from 200 to 250 mg/kg [8,9]. The majority of spermidine in standard diets comes from whole grains, apples, pears, salad, vegetable sprouts and potatoes[10].

PlantPills Whole-Food Spermidine has by far the highest spermidine content of any whole food, independently verified to contain over 900 mg/kg (over 0.9mg per gram).

The average person is estimated to consume approximately 10 mg per day [10], though this varies from around 7mg to 25mg or more, with the highest amounts present in the Mediterranean diet, often associated with good health and longevity[19,20,21].

A large human study published in 2018, conducted on 829 people over a 20 year period, found that people with a diet rich in spermidine had an increased survival rate equivalent to 6 years over those with less dietary spermidine [10].

The study analysed 146 nutrients, and found spermidine to have the strongest link of any nutrient to increased survival.

These findings were independently validated in a second study, with the diets and mortality of 1,770 healthy unrelated people analysed[10-supp.tab.9].

This corroborates previous studies that found spermidine supplementation significantly increased lifespan in yeast (40-150%), worms (10-15%), flies (15-20%) and mice (10-25%) [11,12,13].

Tissue spermidine concentrations decline with age [14,15,16,17], which may in part be due to a decline in the biosynthetic activities of polyamine-producing enzymes as they become less efficient[18]. Interestingly, the age-related decline in spermidine levels doesn’t occur in naked mole-rats, that live 10 times longer than other rodent species of the same size[43].

It has been theorised that because the body produces sufficient spermidine during youth, but not in old age, that spermidine evolves to the status of a vitamin and should be supplemented for health maintenance [44].

Pure spermidine is classified as a research chemical, and cannot be used for human consumption, so spermidine can only be supplemented via whole food or extract sources.

PlantPills Whole-Food Spermidine has by far the highest spermidine content of any whole food, independently verified to contain over 900 mg/kg (over 0.9mg per gram). The spermidine content test certificate from the third-party laboratory for the current batch can be seen in the images section.

PlantPills Whole-Food Spermidine is a specific strain of chlorella, a tiny single-celled green alga that lives in fresh water. It's a plant that is about the same size as a human red blood cell, and has existed on earth for over 3 billion years.

Chlorella is very well studied in humans and animals, and is a dietary staple in some parts of the world, with over 7 million people in Japan consuming chlorella on a daily basis.

Our significant experience and expertise with alga has enabled us to cultivate specific strains, that when grown in the correct conditions [46], result in the highest whole-food source of spermidine in the world.

Every batch of PlantPills Whole-Food Spermidine is independently verified to have a spermidine content of at least 900mg per kg, with no dangerous levels of heavy metals or micro-organisms. The certifications for the current batch are viewable in the images section. The current batch of our Whole-Food Spermidine has a spermidine content of 970 mg per kg.

Pack sizes are 250 grams, 500 grams, 1 kilogram, 2 kilograms and 10 kilograms.