The 2001-S Proof Set contained ten coins: One of each of the Lincoln Cent, Jefferson Nickel, Roosevelt Dime (Copper-Nickel Clad), Kennedy Half Dollar (Copper-Nickel Clad), Sacagawea "Golden" Dollar, New York Quarter (Copper-Nickel Clad), North Carolina Quarter (Copper-Nickel Clad), Rhode Island Quarter (Copper-Nickel Clad), Vermont Quarter (Copper-Nickel Clad) and Kentucky Quarter (Copper-Nickel Clad).

About the sets: All coins in the 2001-S Proof Set were intended to have a Cameo or Deep Cameo Finish. Mintage limits for the 2001-S Proof Set were initially capped at 2.3 million, with a cut-off date of May 31, 2001. Later, the caps were lifted, but sales still fell short of the goal. On May 15, 2002, the Mint announced that "unsold remaining inventory" consisting of 1999-S, 2000-S, and 2001-S Proof Sets would be offered in a three-set combination beginning on May 29, 2002. The price was $94.95 for the three-set combination (or $79.95 if more than 100 combinations were ordered). No limits were placed on individual orders but total orders were limited to the available quantities of 150,000 three-set combinations. Almost immediately thereafter, the Mint announced that sales of the three-set combination would cease because of unspecified damage the sets suffered while in storage. All of the remaining sets were to have been destroyed.