Publisher Description

Biochemistry is the organic chemistry of compounds and processes occurring in organisms. Histocytochemistry is the study of intracellular distribution of chemical, reaction sites, enzymes, etc. by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods. This book focuses on the role of norepinephrine in neuroinflammation, discusses the contribution of norepinephrine to Alzheimer's (AD) and Parkinson's Disease (PD) and provides an overview of potential therapeutical options targeting this neurotransmitter. Using methodologies such as questionnaires and laboratory tasks, experimental results showing specific effects related to noradrenaline in both clinical and experimental studies are described. This book also provides the current findings on the relationships between sympathetic nerve activity, B-adrenoceptor polymorphisms, and renal function. Recent methodologies that are useful for advanced immunohistochemistry (IHC) analysis in pathological research into therapeutic agents is also analysed.Other chapters in this book discuss the unresolved areas of plasma cell research, an analysis of a new technology based on B-Cell targeting and its advantages over conventional methods for selective generation of novel monoclonal antibodies, as well as a review of the regulation of proteases and their role during the biocontrol process. Recent advances in the isolation and characterisation of glycosidases from hyperthermophilic microorganisms and the methods used for their application in oligosaccharide synthesis are explored as well.

Table of Contents

Preface; Function of Norepinephrine in Neuroinflammation & Chronic Neurodegenerative Diseases; The Role of Noradrenaline on Interpersonal Functioning; Role of Norepinephrine in Affective Disorders; The Role of Sympathetic Nerve Activity in Renal Injury; Quantitative Immunohistology - Problems & Solutions; Immunohistochemical Basis for Orthodontic Treatment; Pathological Research on Molecular-Targeted Therapy & Advanced Immunohistochemical Approaches; Pre-embedding Scarce Biological Specimens for Light & Electron Microscopy; Role of Surrogate Light Chain Expressing B Cells in the Formation of Self-reactive Antibodies; A Novel Method for Generation of Monoclonal Antibodies; Unique Enzymes of Aspergillus Fungi used in Japanese Bioindustries; Extracellular Proteases of Entomopathogenic Fungi; Glycoside Hydrolases from Hyperthermophiles: Structure, Function & Exploitation in Oligosaccharide Synthesis; Studies on the Thermal Stability of the Therapeutic Enzyme L-Asparaginase from Erwinia Carotovora; Index.

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