Publisher Description

Chromosomal aberrations are disruptions in the normal chromosomal content of a cell, and are a major cause of genetic conditions in humans, such as Down syndrome. Some chromosome abnormalities do not cause disease in carriers, such as translocations, or chromosomal inversions, although they may lead to a higher chance of having a child with a chromosome disorder. Abnormal numbers of chromosomes or chromosome sets, aneuploidy, may be lethal or give rise to genetic disorders. Genetic counseling is offered for families that may carry a chromosome rearrangement. This book offers leading-edge research from around the world.

Table of Contents

Preface; The Role of Gene Translocations in the Molecular Pathogenesis of Acute Myeloid Leukaemia; Chromosomal Translocations and Fusion Genes in Human Soft Tissue Sarcomas; Translocations as Tools for Understanding Control of Sex Determination in the Silkworm, Bombyx Mori; Augmented Translocation of Nuclear Factor-UB into Nuclei and Down-regulation of Apoptosis Related Gene Expression by Nipradilol, a Nonselective B- and selective a1 Vblocker, is Related to Cytoprotection; PRINS for Detection of Unique Chromosome Sequences and Single Gene Deletions; Efficiency of Intrachange Formation at Low Doses is Determined by Condensation State of Interphase Chromosomes; Centromeric Breakage and Illegitimate Recombination Leads to Whole Arms Translocations in Squamous Cell Carcinoma; Fragile Sites on Human Chromosomes; Novel and Uncommon Chromosome Aberrations in Chronic Lymphocytic Leukemia: Cytogenetic, FISH and Clinical Evaluation; Constitutional Chromosome Aberrations in Hematologic Disorders: Evaluation of 4884 Patients from a Sole Institution; Index.

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