Title: Cell
Type: Medical Journal
Publisher: Cell Press / Cell Press Journals
Frequency: Bi-Weekly
Volume: 171
Issue Number: 6
Date Released: November 30, 2017
Features:
- Colorful
- Resourceful
- Informative & Cutting-Edge
- Peer Reviewed Studies!
Table of Contents: Leading Edge
■ ■ BENCH TO BEDSIDE ■ ■
- 981 ➥ First Approved Kinase Inhibitor for AML by J.E.J. Rasko and T.P. Hughes
■ ■ COMMENTARY ■ ■
- 982 ➥ Core Clinical Data Elements for Cancer Genomic Repositories: A Multi-stakeholder Consensus ➥ by R.B. Conley, D. Dickson, J.C. Zenklusen, J. Al Naber, D.A. Messner, A. Atasoy, L. Chaihorsky, D. Collyar, C. Compton,
M. Ferguson, S. Khozin, R.D. Klein, S. Kotte, R. Kurzrock, C.J. Lin, F. Liu, I. Marino, R. McDonough, A. McNeal, V. Miller, R.L. Schilsky, and L.I. Wang
■ ■ PREVIEWS ■ ■
- 987 ➥ Cancer Evolution: No Room for Negative Selection ➥ by S.F. Bakhoum and D.A. Landau
- 989 ➥ Tuning Biased GPCR Signaling for Physiological Gain ➥ by S. Spangler and M.R. Bruchas
- 992 ➥ Risky Business: The Circuits that Impact Stress-Induced Decision-Making ➥ by A.F.T. Arnsten, D. Lee, and C. Pittenger
■ ■ PERSPECTIVE ■ ■
- 994 ➥ Rethinking Unconventional Translation in Neurodegeneration ➥ by F.-B. Gao, J.D. Richter, and D.W. Cleveland
■ ■ REVIEW ■ ■
- 1001 ➥ Specification of Physiologic and Disease States by Distinct Proteins and Protein Conformations ➥ by D.F. Jarosz and V. Khurana
■ ■ SNAPSHOT ■ ■
- 1224 ➥ Functions of Endoplasmic Reticulum Membrane Contact Sites ➥ by R. Salvador-Gallego, M.J. Hoyer, and G.K. Voeltz
■ ■ ARTICLES ■ ■
- 1015 ➥ Wild Mouse Gut Microbiota Promotes Host Fitness ➥ by S.P. Rosshart, B.G. Vassallo, D. Angeletti, D.S. Hutchinson, A.P. Morgan, K. Takeda, H.D. Hickman, J.A. McCulloch, J.H. Badger, N.J. Ajami, G. Trinchieri, F. Pardo-Manuel de Villena, J.W. Yewdell, and B. Rehermann
- 1029 ➥ Universal Patterns of Selection in Cancer and Somatic Tissues ➥ I. Martincorena, K.M. Raine, M. Gerstung, K.J. Dawson, K. Haase, P. Van Loo, H. Davies, M.R. Stratton, and P.J. Campbell
- 1042 ➥ Comprehensive Analysis of Hypermutation in Human Cancer ➥ by Various Contributors
- 1057 ➥ Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation ➥ by E.V. Dang, J.G. McDonald, D.W. Russell, and J.G. Cyster
- 1072 ➥ Structural Basis of Mitochondrial Transcription Initiation ➥ by H.S. Hillen,Y.I. Morozov, A. Sarfallah, D. Temiakov, and P. Cramer
- 1082 ➥ Mechanism of Transcription Anti-termination in Human Mitochondria ➥ by H.S. Hillen, A.V. Parshin, K. Agaronyan, Y.I. Morozov, J.J. Graber, A. Chernev, K. Schwinghammer, H. Urlaub, M. Anikin, P. Cramer, and D. Temiakov
- 1094 ➥ NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis ➥ by S.B. Widenmaier, N.A. Snyder, T.B. Nguyen, A. Arduini, G.Y. Lee, A.P. Arruda, J. Saksi, A. Bartelt, and G.S. Hotamisligil
- 1110 ➥ The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3 ➥ M.M. Gaidt, T.S> Ebert, D. Chauhan, K. Ramshorn, F. Pinci, S. Zuber, F. O'Duill, J.L. Schmid-Burgk, F. Hoss, R. Buhmann, G. Wittmann, E. Latz, M. Subklewe, and V. Hornung
- 1125 ➥ Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program ➥ by F. Dotiwala, S. Sen Santara, A.A. Binker-Cosen, B. Li, S. Chandrasekaran, and J. Lieberman
- 1138 ➥ Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy ➥ by L. Nissim, M.-R. Wu, E. Pery, A. Binder-Nissim, H.I. Suzuki, D. Stupp, C. Wehrspaun, Y. Tabach, P.A. Sharp, and T.K. Lu
- 1151 ➥ Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States ➥ by H. Stroud, S.C. Su, S. Hrvatin, A.W. Greben, W. Renthal, L.D. Boxer, M.A. Nagy, D.R. Hochbaum, B. Kinde, H.W. Gabel, and M.E. Greenberg
- 1165 ➥ Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics ➥ by C.L. Schmid, N.M. Kennedy, N.C. Ross, K.M. Lovell, Z. Yue, J. Morgenweck, M.D. Cameron, T.D. Bannister, and L.M. Bohn
- 1176 ➥ Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice ➥ by Y. Li, A. Mathis, B.F. Grewe, J.A. Osterhout, B. Ahanonu, M.J. Schnitzer, V.N. Murthy, and C. Dulac
- 1911 ➥ Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making ➥ by A. Friedman, D. Homma, B. Bloem, L.G. Gibb, K.-i. Amemori, D. Hu, S. Delcasso, T.F. Truong, J. Yang, A.S. Hood, K.A. Mikofalvy, D.W. Beck, N. Nguyen, E.D. Nelson, S.E. Toro Arana, R.H. Vorder Bruegge, K.A. Goosens, and A.M. Graybiel
■ ■ RESOURCE ■ ■
- 1206 ➥ Classifying Drosophila Olfactory Projection Neuron Subtypes ➥ by Single-Cell RNA Sequencing by H. Li, F. Horns, B. Wu, Q. Xie, J. Li, T. Li, D.J. Luginbuhl, S.R. Quake, and L. Luo
■ ■ CORRECTION ■ ■
- 1221 ➥ A Distinct Gene Module for Dysfucntion Uncoupled from Activation in Tumor-Infiltrating T Cells ➥ by M. Singer, C. Wang, L. Cong, N.D.
■ ■ ANNOUNCEMENTS ■ ■
■ ■ POSITIONS AVALABLE ■ ■
■ ■ ON THE COVER ■ ■
- ➥ In this issue, Gaidt et al. (1110-1124) report the role of the cGAS-STING axis in driving a lysosomal cell death program to activate the NLRP3 inflammasome during cytosolic DNA sensing in human myeloid cells. The cover art is inspired by the ability of STING signaling to drive death and inflammation, whereby DNA initiates a powerful dance of the cGAS-STING pathway to ignite an explosive destruction depicting lysosomal cell death and inflammasome activation. Artwork by Atelier Uta Polster.
Origin: Cambridge, Massachusetts (MA)
Country: Printed in the USA / United States / U.S.A.
Condition: Like New!
We Accept Offers!