St. Francis Hospital was founded in 1874 by the Sisters of St. Francis of Philadelphia. The hospital was introduced a plaque in honor of President John F. Kennedy 1968. Today, the plaque is placed at the corner of Hamilton Ave. and Chambers St. The building consists of a parking lot, emergency entrance (which has an entrance for only ambulances), and a main building.

Capital Health entered an agreement to purchase St. Francis Medical Center in 2022 and assumed operational control starting at midnight on 12/21/22. It was renamed Capital Health- East Trenton.