Cast overview:
| Kerry Washington | Olivia Pope (106 episodes, 2012-2017) | |
| Guillermo Díaz | Huck (106 episodes, 2012-2017) | |
| Katie Lowes | Quinn Perkins (98 episodes, 2012-2017) | |
| Darby Stanchfield | Abby Whelan (98 episodes, 2012-2017) | |
| Jeff Perry | Cyrus Beene (98 episodes, 2012-2017) | |
| Joshua Malina | David Rosen (97 episodes, 2012-2017) | |
| Bellamy Young | Mellie Grant / ... (98 episodes, 2012-2017) | |
| Tony Goldwyn | President Fitzgerald Grant (98 episodes, 2012-2017) | |
| Scott Foley | Jake Ballard (77 episodes, 2013-2017) | |
| Joe Morton | Rowan Pope / ... (62 episodes, 2013-2017) | |
| Columbus Short | Harrison Wright (47 episodes, 2012-2014) | |
| Portia de Rossi | Elizabeth North (46 episodes, 2014-2017) | |
| George Newbern | Charlie (44 episodes, 2012-2017) |