Alice (Milla Jovovich), now
in hiding in the Nevada desert, once again joins forces with Carlos Olivera
(Oded Fehr) and LJ (Mike Epps), along with new survivors, Claire (Ali Larter),
K-Mart (Spencer Locke) and Nurse Betty (Ashanti) to try to eliminate the deadly
virus that threatens to make every human being 'undead'. Since being captured
by the Umbrella Corporation, Alice has been subjected to biogenic
experimentation and becomes genetically altered, with super-human strengths,
senses and dexterity. These skills and more will be needed if anyone is to
remain alive.