Spider-Man's life is thrown into turmoil as he begins to undergo a shocking transformation - one that may well leave the web-slinger scarred forever! What is the cause of this strange mutation - and how does it connect to the troubles plaguing the Avengers? 

Betrayed by his body and suffering the painful effects of his slow transformation from man to arachnid, Spidey must confront the architect of his metamorphosis - the Queen! But only Captain America holds the key to her defeat!