SCHEDA CATALOGRAFICA :

Antiglobulins, cryoglobulins and glomerulonephritis

Autori Vari

Nijhoff

1986

edited by Claudio Ponticelli, Luigi Minetti, Giuseppo D’Amico
X, 303 p. : ill. ; 24 cm.
(Developments in nephrology ; 16)

About this book :
RICHARD J. GLASSOCK Introducing a scientific symposium is an uncertain and difficult task. The remarks must not be too specific lest the participant’s later contributions be intruded upon, yet an overview of the goals and objectives of the conference should be presented in an inquisitive and stimulating fashion. Perhaps a compromise position would be to make a few general statements and pose a limited number of questions which hopefully would then be addressed dur­ ing the formal or informal portions of the meeting. A conclusion incorpo­ of the relevance of the specific topic to the more rating some perspectives global issues of disease and its consequences might be appropriate. The goals and objectives of this conference, as set forth by its organizers, Professors Ponti celli, D’Amico and Minetti, are rather simple and straight­ forward; namely, to review and elucidate the immunopathophysiology of cryoimmunoglobulins and auto-antibodies to immunoglobulins (lg) and, secondarily, to explore the possible participation of these disordered states in glomerular injury. As such, this conference is principally devoted to an analysis of two properties of certain species of the globulin fraction of serum proteins, specifically the ability to self associate on the basis of immune interactions and to form insoluble aggregates when exposed to reduced ambient temperature. As we shall see, these two properties are often dis­ tinctly related.

Table of contents (25 chapters) :
- List of First Authors
- Introduction / Richard J. Glassock

Part 1 : Physiology and pathology of antiglobulins
- Subsets of rheumatoid factors determined by cross idiotypes / Vincent Agnello
- Structure and function of rheumatoid factor: implications for its role in the pathogenesis of mixed cryoglobulinemia / Robert D. Goldfien ... [eta l.]
- Regulatory Idiotopes and Diseases / Constantin A. Bona
- Discussion

Part 2 : Role of antiglobulins in experimental glomerulonephritis
- Pathogenetic mechanisms of infective endocarditis glomerulonephritis in the rabbit / Patrick Naish
- Interaction of Human IgM Rheumatoid Factors with Immune Complexes in Experimental Murine Glomerulonephritis / Peter M. Ford
- Anti-Idiotypic Antibodies in Glomerulonephritis and in Tubulointerstitial Nephritis Models of Immune Renal Injury / Curtis B. Wilson ... [et al]
- Experimental analysis of the generation of pathogenic immune complexes resulting from immonoblogulin interactions / P.H. Lambert ... [et al.]
- Discussion

Part 3 : Classification of cryoglobulins and biochemical factors inducing, cryoprecipitation
- Classification of Cryoglobulinemias / C. Zanussi ... [et al.]
- Intrinsic properties inducing precipitation of cryoglobulins / An-Chuan Wang and Irene Y. Wang
- Cryoprecipitation as a consequence of globulin-antiglobulin interactions / G.N. Abraham ... [et al.]
- Fibronectin is a regular component of single-type and mixed cryoglobulins / Franco Dammacco e Giuseppe Gallo
- Discussion

Part 4 : Immunological aspects of essential mixed cryoglobulinemia
- Complement activation in patients with mixed cryoglobulinemia (cryoglobulins and complement) / Irma Gigli
- Human type II mixed cryoglobulins as a model of idiotypic interactions / J.C, Renversez ... [et al.]
- Monoclonal antibodies to idiotypic determinants on monoclonal rheumatoid factors — application to patients with type II cryoglobulinemia / M. Ono ... [et al.]
- Discussion

Part 5 : Clinical and morphological findings in E.M.C.
- Mixed Cryoglobulinemia: An Update of Recent Clinical Experience / Peter D. Gorevic
- Histological and immunohistological features in essential mixed cryoglobulinemia glomerulonephritis / Franco Ferrario ... [et al.]
- Clinical and histological correlations in essential mixed cryoglobulinemia (EMC) glomerulonephritis / Giovanni Barbiano Di Belgiojoso ... [et al.]
- Ultrastructural features in glomerulonephritis in essential mixed cryoglobulinemia / M.J. Mihatsch and G. Banfi
- Prognostic factors in essential mixed cryoglobulinemia nephropathy / A. Tarantino ... [et al.]
- Discussion

Part 6 : Round table on different therapeutic regimens in the management of E.M.C. patients
- Long term management of essential mixed cryoglobulinemia / Daniel J. Cordonnier ... [et al.]
- Effects of cryoapheresis on plasma cryoglobulins and renal function in patients with EMC glomerulonephritis / Q. Maggiore ... [et al.]
- Treatment of renal disease in essential mixed cryoglobulinemia / C. Ponticelli ... [et al.]
- Long term treatment of mixed cryoglobulinemia (MCG) / David Geltner
- Concluding remarks / J. Stewart Cameron

- Index of subjects

NUOVO (Copertina rigida editoriale) (Illustrazioni in bianco e nero)
(Prezzo dell’Editore Euro 83,15)