50/50 is a 2011 American comedy-drama film directed by Jonathan Levine, written by Will Reiser, and starring Joseph Gordon-Levitt, Seth Rogen, Anna Kendrick, Bryce Dallas Howard, and Anjelica Huston. The film is loosely inspired by Reiser's own experience with cancer, with Rogen's character Kyle based on Rogen himself. It was filmed from February to March 2010. 50/50 was released on September 30, 2011, and grossed $41 million. It received critical acclaim, with particular praise for Gordon-Levitt's performance and Reiser's screenplay.
Mild-mannered Adam Lerner is a 27-year-old public radio journalist in Seattle. His best friend Kyle, who is rather crude, disapproves of his girlfriend Rachael, an artist. After experiencing severe pains in his back, Adam is diagnosed with schwannoma neurofibrosarcoma, a cancerous tumor in his spine, and must undergo chemotherapy. He sees on the Internet that the survival rate for his diagnosis is 50/50. After Adam reveals this, his emotional mother, Diane, who nurses her Alzheimer's-stricken husband Richard, offers to care for him, but Adam declines as Rachael has already promised to do so.
At one of his treatments, Adam meets Mitch and Alan, two older cancer patients also undergoing chemo, and they become friends, bonding through cannabis-laced macaroons. Rachael is uncomfortable during his treatments and is often late picking him up. She also gets him a retired racing greyhound named Skeletor as a pet. Throughout Adam's struggle, Kyle attempts to keep up his morale, helping Adam shave his head and using his friend's illness to pick up women. While on a date, Kyle sees Rachael kissing another man at a gallery and later forces her to confess her infidelity to Adam, who breaks up with her. He follows Kyle's suggestion, and they use his illness to pick up two women at a bar.
Meanwhile, Adam is being treated by a young, inexperienced therapist, Katherine McKay, a Ph.D. candidate doing the clinical aspect of her thesis at the hospital. While their relationship and sessions begin unevenly, he slowly opens up to her. After she drives him home following a chemo session, they develop a rapport, blurring their professional and personal relationship. She helps Adam understand his mother's situation: loved ones can feel just as much stress as the patient, which helps Adam repair the rift between him and his mother.
When Mitch dies, Adam's mortality hits him, causing him to lash out at Katherine verbally, and shortly after, he is informed that he needs to undergo a risky surgery. The night before the operation, Adam argues with an intoxicated Kyle, demanding that he let him drive his car even though he has never learned and has no driver's license. After a near miss, Adam breaks down and accuses Kyle of being more concerned with using the cancer for his own gain than taking his condition seriously. Adam then calls Katherine and tells her he wishes she was his girlfriend, but he also says he is tired of being sick and just wants his cancer to be over. That night, dropping off Kyle (who was too drunk to drive), Adam finds the book Facing Cancer Together from their trip to a bookstore, where Kyle picked up a shop clerk. The book is filled with notes, highlighted paragraphs, and turned-down pages. He realizes that Kyle sincerely cares about him and has earnestly tried to help him since his diagnosis.
The next day, Kyle drops Adam off at the hospital, where Adam embraces him for being a good friend and apologizes for the previous night. After saying his tearful farewells to his family, he undergoes surgery. Katherine goes to the waiting room and inadvertently meets Adam's parents and Kyle during the wait. After the surgery, they are told that although the bone degradation was worse than they believed, the surgeons removed the tumor successfully, and Adam will recover. Sometime later, he prepares for a date with Katherine while Kyle encourages him and bandages the incision on his back. After Kyle leaves, Katherine asks, "Now what?" and Adam smiles, finally free of cancer.
The screenplay is loosely based on the experience of screenwriter Will Reiser, friend of the film's co-lead, Seth Rogen. Reiser is also close with Evan Goldberg of Da Ali G Show. The title of Reiser’s script was I'm with Cancer, but executives at Summit Entertainment changed the title of the film so as not to alienate audiences from the film’s subject matter. The film was later renamed Live with It and then 50/50.
James McAvoy was going to play the lead role before he left the film due to personal reasons, as he was afraid of missing the birth of his first child, and was replaced by Joseph Gordon-Levitt.
Principal photography took place in Vancouver over a five-week period, beginning in March 2010.
The head-shaving scene in the film was featured on the movie posters and commercials. At the 50/50 premiere in New York, Gordon-Levitt said, "We only had one take because you can't shave your head twice." Rogen recalled, "It was the first day of filming, and we improvised the whole thing, which is not wise when it's something you have one take for, but it turned out funny."