Dutch Post-Impressionist painter Vincent van Gogh painted a self-portrait in oil on canvas in September 1889. The work, which may have been Van Gogh's last self-portrait, was painted shortly before he left Saint-Rémy-de-Provence in southern France. The painting is now at the Musée d'Orsay in Paris. This self-portrait was one of about 32 produced over a 10-year period, and these were an important part of his work as a painter; he painted himself because he often lacked the money to pay for models. He took the painting with him to Auvers-sur-Oise, near Paris, where he showed it to Dr. Paul Gachet, who thought it was "absolutely fanatical".

Art historians are divided as to whether this painting or Self-portrait without beard is Van Gogh's final self-portrait. Art historians Ingo F. Walther and Jan Hulsker consider this to be the last, with Hulsker considering that it was painted in Arles following Van Gogh's admission to hospital after mutilating his ear, while Ronald Pickvance thinks Self-portrait without beard was the later painting. Van Gogh sent the picture to his younger brother, the art dealer Theo; an accompanying letter read: "You will need to study [the picture] for a time. I hope you will notice that my facial expressions have become much calmer, although my eyes have the same insecure look as before, or so it appears to me."