Müller scored 68 goals in 62 games for West Germany.[7] He was Germany's all-time leading scorer for almost 40 years until surpassed by Miroslav Klose in 2014, though Klose required over double the number of caps to do so, scoring his 69th goal in his 132nd appearance.[13] Müller's international career started in 1966 and ended on 7 July 1974 with victory at the 1974 World Cup at his home stadium in Munich.[14] He scored the winning goal for the 2–1 victory over Johan Cruyff's Netherlands in the final. His four goals in that tournament and his ten goals at the 1970 World Cup combined made him the all-time highest World Cup goalscorer at the time with 14 goals. His record stood until the 2006 tournament, coincidentally held in Germany, when it was broken by Brazilian striker Ronaldo, who also required more matches than Müller to achieve his tally.[5] Müller also participated in the 1972 European Championship, becoming top scorer with four goals (including two in the final) and winning the Championship with the West German team.[7]

Müller quit playing for West Germany after the 1974 World Cup triumph following an argument with the German Football Association at the post-tournament celebration, when officials' wives were allowed to attend but players' wives were not.