The American League jumped out to a 1-0 lead in the 2nd inning led by a home run by Edgar Martínez of the Seattle Mariners. No one would score after that until the 7th inning when Javy López of the Atlanta Braves would tie the game with a home run of his own. However, in the bottom of the 7th, Sandy Alomar, Jr. of the Cleveland Indians hit a two-run home run to give the American League the lead and the win, as they held on to defeat the National League 3-1 and Alomar became the first player in All-Star Game history to win All-Star Game MVP as a member of the host team.

The loudest ovation of the All-Star Game, which came early in the player introductions, was reserved for Kenny Lofton, whom the Indians had traded to the Atlanta Braves prior to the start of the 1997 season. Lofton was on the National League roster, but was injured and did not play. Also in the pregame ceremonies, Albert Belle, who was representing the Chicago White Sox, was booed for leaving the Indians as a free agent the previous winter.

Unlike past years, the performance of O Canada, this year by the McAuley Boys, was not televised. Instead, the Fox network, airing its first All-Star Game, went into a commercial break, resulting in angry phone calls from Canadian television viewers. The Canadian National Anthem was later shown on tape delay after the game in the Cleveland area. Country star LeAnn Rimes sang the National Anthem following the commercial break. To commemorate the 50th anniversary of baseball's breaking of the color barrier, the ceremonial first pitch featured former Indian Larry Doby, the first African-American player to play in the American League.

One of the more colorful moments in All-Star Game history occurred during an at bat with Randy Johnson of the Seattle Mariners pitching and Larry Walker of the Colorado Rockies at the plate. The teams of the two former Montreal Expos teammates had faced each other about one month prior. However, when Johnson started on June 12, Walker chose not to play, explaining that, "I faced Randy one time in spring training and he almost killed me."[2] In this All-Star Game, Walker batted against Johnson, who theatrically threw over his head. Ever adaptable, Walker placed his batting helmet backwards and switched sides in the batters' box to stand right-handed for one pitch. He ended the at bat by drawing a walk.[3] The incident momentarily drew mirth and laughter from players in both dugouts, fans and announcers, and comparisons to Johnson pitching against John Kruk in the 1993 All-Star Game, in which he also threw over his head.[4] In spite of garnering a reputation of avoiding Johnson,[5] Walker batted .393 (11 hits in 28 at bats) against him in his career,[6] nearly double the rate of all left-handed batters at .199.[7]

After the game, Major League Baseball CEO Paul Beeston presented Alomar with the All-Star Game MVP Award in lieu of the Commissioner of Baseball, who would not be named until after the next All-Star Game, when then-Chairman of the Executive Committee Bud Selig was officially named Commissioner.

This was the last All-Star Game in which the Milwaukee Brewers were represented as a team from the American League. The Brewers switched over to the National League for the 1998 season as a result of the expansion franchises in Arizona and Tampa.