Discover the link between the latest chemical biology approaches and novel drug therapies!
Protein Targeting with Small Molecules: Chemical Biology Techniques and
Applications takes readers beyond the use of chemical biology in basic
research, providing a highly relevant look at techniques that can
address the challenges of biology and drug design and development.
This indispensable bench companion features up-to-date coverage of
advances in chemistry and assesses their impact on developing new
therapeutics, making it ideal for chemical biologists and medicinal
chemists who are developing small molecule drugs to target proteins and
treat diseases. In addition, the book examines the full range of complex
biological systems and their interrelationship with chemistry, from the
interaction of biological response modifiers with proteins to the
chemical biology of cell surface oligosaccharides.
Distinguished by an overview of chemical biology that is reinforced and
clarified by detailed examples and descriptions of techniques, Protein
Targeting with Small Molecules: Chemical Biology Techniques and
Applications:
* Introduces key technologies and methods of chemical biology designed
to detect the interactions of small molecules and proteins
* Facilitates the discovery of small molecules that bind to proteins and
describes the molecules' application in the investigation of biological
processes
* Presents timely coverage of the development of fluorescent probes for
small molecules, as well as the generation of small molecule ligands and
inhibitors
* Reviews important techniques such as chemical genomics, target
profiling, immobilization technology, detection methods, chemical
inhibition, and structure-based targeting
* Offers a compelling synopsis of data that underscores the recent
progress made in the area of targeting proteins by small molecules