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Sam & Dave were an American soul and R&B duo who performed together from 1961 until 1981. The tenor (higher) voice was Sam Moore (born 1935) and the baritone/tenor (lower) voice was Dave Prater (1937–1988).

Nicknamed "Double Dynamite", "The Sultans of Sweat", and "The Dynamic Duo" for their gritty, gospel-infused performances, Sam & Dave are considered one of the greatest live acts of the 1960s. Many subsequent musicians have named them as an influence, including Bruce Springsteen, Al Green, Tom Petty, Phil Collins, Michael Jackson, Steve Van Zandt, Elvis Costello, The Jam, Teddy Pendergrass, Billy Joel, and Steve Winwood. The Blues Brothers, who helped create a resurgence of popularity for soul, R&B, and blues in the 1980s, were influenced by Sam & Dave – their biggest hit was a cover of "Soul Man", and their act and stage show contained many homages to the duo.