While being transported to Death Row, a freak train accident allows him to break free from the custody of Lt Philip Gerard (Barry Morse). While Gerard chases down Kimble, the good doctor is on a quest to find his wife's real killer the one-armed man whom Kimble witnessed fleeing the scene of the crime. Switching identities while helping strangers in need along the way, Kimble's life is constantly on the move...but he will not stop until justice is found.