The 2001 Southeast Asian Games (Malay: Sukan Asia Tenggara 2001), officially known as the 21st Southeast Asian Games, was a Southeast Asian multi-sport event held in Kuala Lumpur, Malaysia. This was the fifth time that Malaysia plays as SEA Games hosts, the country previously held the event in 1965, 1971, 1977, and 1989, all of which were staged in Kuala Lumpur.

Held from 8 to 17 September 2001 (although several events had commenced from 1 September 2001), these were the first SEA Games to have taken place in the new millennium. Around 4,165 athletes have participated at the Kuala Lumpur Games, which featured 391 events in 32 sports. It was opened by Salahuddin, the King of Malaysia at the Bukit Jalil National Stadium.

The final medal tally was led by host Malaysia, followed by Thailand and Indonesia. Several Games and National Records were broken during the games. The games were deemed generally successful with the rising standard of competition amongst the Southeast Asian nations.

Sukan Asia Tenggara 2001 (bahasa Inggeris: 2001 Southeast Asian Games), secara rasminya dikenali sebagai Sukan Asia Tenggara ke-21 (bahasa Inggeris: 21st Southeast Asian Games) merupakan temasya sukan Asia Tenggara yang pernah diadakan di Kuala Lumpur, Malaysia. Kali ini merupakan kali kelima Malaysia menganjurkan Sukan Asia Tenggara dan juga kali pertamanya sejak 1989. Sebelum ini, Malaysia juga menganjurkan temasya 1965, temasya 1971 dan temasya 1977.

Temasya sukan ini merupakan Sukan Asia Tenggara yang pertama pada abad ke-21, dan temasya yang pertama pada alaf ke-3. Kira-kira 4165 atlet dari 10 negara peserta menyertai temasya sukan tersebut yang menampilkan 391 acara dalam 32 sukan. Temasya sukan ini diadakan dari 8 hingga 17 September 2001, walaupun beberapa acara telah berlangsung dari 1 September 2001. Temasya sukan dibuka oleh Yang di-Pertuan Agong, Sultan Salahuddin di Stadium Nasional Bukit Jalil.

Tuan rumah Malaysia digelar juara keseluruhan mengikut jadual pingat rasmi, diikuti Thailand dan Indonesia dari belakang. Beberapa rekod Asia, temasya dan kebangsaan telah dipecahkan ketika temasya sukan berlangsung. Dengan sedikit atau tanpa kontroversi, temasya sukan tersebut secara umumnya diadakan dengan jayanya dengan peningkatan taraf pertandingan antara negara Asia Tenggara.