Combat medic and biochemist Rebecca Chambers, the sole survivor of Bravo Team, joins a new S.T.A.R.S. strike force when rumor comes of another Umbrella experiment. Hidden beneath the rocky cliffs of Caliban Cove, Maine, someone is building an army of the undead.

Now the S.T.A.R.S. must battle more unspeakable horrors and stop a madman from unleashing the biohazard upon the world.