#1 cardiologist recommended Ecotrin® 325mg regular strength aspirin is enteric safety coated and designed to dissolve safely in your small intestine. Higher dosages of aspirin are usually needed to relieve headaches and minor arthritis pain. Taking aspirin daily may reduce the risk of heart attacks and certain strokes, but speak to your doctor first about whether aspirin is right for you. Ecotrin® is always enteric safety coated and designed to dissolve safely in your small intestine. That’s why Ecotrin® is the aspirin regimen that’s smart for your heart and stomach. For the temporary relief of minor aches and pains due to: