Acetyl L-Carnitine is a molecule that occurs naturally in the brain, liver and kidney and diminish as we age. Some of the primary used of acetyl L-Carnitine are as follows:
Acetyl L-Carnitine is a stabilized and more absorbable form of the amino acid L-Carnitine. Acetyl L-Carnitine plays an important role in protecting and supporting brain and muscle function. As an antioxidant, Acetyl L-Carnitine protects neurons from damage caused by superoxide radicals.
Acetyl L-Carnitine is involved in aspects of neuronal metabolism because its molecular structure resembles the neurotransmitter acetylcholine. Supplementing with Acetyl L-Carnitine may improve acetylcholine production and stimulation of protein and membrane phospholipid synthesis.
Research on Acetyl L-Carnitine shows it can be very useful in supporting normal brain function, and possibly be useful for strokes, Down's syndrome and the management of various neuropathies. The effects of supplementing with Carnitine arnitine has been extensively researched in many areas, including exercise performance, weight loss, treatment of
Alzheimer's,
Parkinson's, diabetic neuropathy, depression and other neurological
disorders, treatment of alcoholism, treatment of cardiovascular
diseases, insulin resistance, and many others.
Expiration | 24 months minimum |
Grade | pharmaceutical |
Purity | 99.88%+ purity (HPLC) |
Taste | sour taste |
Solubility | very soluble in water |
Appearance | white crystalline powder |
Odor | vinegar smell, especially strong when first opening |
pH | 2.0~3.0 |
Classification | amino acid |
CAS Registry | 5080-50-2 |
Synonyms | Acetyl L-Carnitine
HCl, R-Acetoxy-4-(trimethylammonio) butyrate HCl |
Molecular Formula | C9H17NO4HCl |
The acetyl group that is part of Acetyl L-Carnitine contributes to the production of the neurotransmitter acetylcholine, which is required for mental function. Several double-blind clinical trials suggest that Acetyl L-Carnitine delays the progression of Alzheimer’s disease and enhances overall performance in some people with Alzheimer’s disease. Alzheimer’s research has been done with the Acetyl L-Carnitine form, rather than the L-carnitine form, of this nutrient.
Several clinical trials have found that Acetyl L-Carnitine supplementation delays the progression of Alzheimer’s disease, improves memory, and enhances overall performance in some people with Alzheimer’s disease. Overall, most short-term studies have shown clinical benefits, and most long-term studies (one year) have shown a reduction in the rate of deterioration.
One double-blind trial has found that Acetyl L-Carnitine may be helpful for people with degenerative cerebellar ataxia, a loss of muscular coordination caused by disease in the cerebellum (the hind part of the brain that controls muscle tone and balance).
Several clinical trials suggest that Acetyl L-Carnitine delays onset of ARCD and improves overall cognitive function in the elderly. In a controlled clinical trial, Acetyl L-Carnitine was given to elderly people with mild cognitive impairment. After 45 days of Acetyl L-Carnitine supplementation at 1,500 mg per day, significant improvements in cognitive function (especially memory) were observed. Another large trial of Acetyl L-Carnitine for mild cognitive impairment in the elderly found that 1,500 mg per day for 90 days significantly improved memory, mood, and responses to stress. The favorable effects persisted at least 30 days after treatment was discontinued. Controlled and uncontrolled clinical trials on Acetyl L-Carnitine corroborate these findings.
Acetyl L-Carnitine may be effective for depression experienced by the elderly. A preliminary trial found that Acetyl L-Carnitine supplementation was effective at relieving depression in a group of elderly people, particularly those showing more serious clinical symptoms. These results were confirmed in another similar clinical trial. In that trial, participants received either 500 mg three times a day of Acetyl L-Carnitine or a matching placebo. Those receiving Acetyl L-Carnitine experienced significantly reduced symptoms of depression compared to those receiving placebo. At least two other clinical studies of Acetyl L-Carnitine for depression in the elderly have reported similar results.
Acetyl L-Carnitine facilitates the metabolism of fatty acids for energy generation. A greater reliance on fat for energy can result in a sparing of muscle glycogen, an enhancement of exercise performance and a reduction in stored body fat. Acetyl L-Carnitine has profound effects on endurance and exercise performance by reducing the respiratory exchange ratio and reducing lactic acid accumulation in muscles extending exercise capacity before fatigue.
Carnitine comes in both L- and D-carnitine forms. However, only the L- form is biologically active. The D- form is completely inactive and in large quantities and particular conditions, the D- form may inhibit the utilization of L-carnitine. L-Carnitine supplements contain no synthetic D-Carnitine or DL-Carnitine. D-Carnitine and DL-Carnitine are less effective than L-Carnitine. D-Carnitine and DL-Carnitine are not recommended because of their adverse physical side effects.
As a dietary supplement, take 1000 mg (1/4 scoop) 1 to 3 times per day preferably on an empty stomach, or as directed by your qualified health consultant. Some powdered items may be hygroscopic and may clump during shipment. This does not effect the efficacy of the product, only the texture. 1 scoop = 4 serving = 4 gram (4000 mg) = 1 teaspoon.
NOT INTENDED FOR USE BY PERSONS UNDER THE AGE OF 18. KEEP OUT OF THE REACH OF CHILDREN. If you are pregnant or breast feeding, consult your health care professional before using this product. People with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking any dietary supplements.