In 1938, the Keanes moved to Beverly Hills, California. While briefly under contract to MGM, Lake enrolled in that studio's acting farm, the Bliss-Hayden School of Acting (now the Beverly Hills Playhouse). She made friends with a girl named Gwen Horn and accompanied her when Horn went to audition at RKO. She appeared in the play Thought for Food in January 1939. A theatre critic from the Los Angeles Times called her "a fetching little trick" for her appearance in She Made Her Bed.
Keane's first appearance on screen was as an extra for RKO, playing a small role as one of several students in the film Sorority House (1939). The part wound up being cut from the film, but she was encouraged to continue. Similar roles followed, including All Women Have Secrets (1939), Dancing Co-Ed (also 1939), Young as You Feel (1940), and Forty Little Mothers (also 1940). Forty Little Mothers was the first time she let her hair down on screen. Lake attracted the interest of Fred Wilcox, an assistant director, who shot a test scene of her performing from a play and showed it to an agent. The agent, in turn, showed it to producer Arthur Hornblow Jr., who was looking for a new girl to play the part of a nightclub singer in a military drama, I Wanted Wings (1940). The role would make Lake, still in her teens, a star.[8] Hornblow changed the actress's name to Veronica Lake. According to him, her eyes, "calm and clear like a blue lake", were the inspiration for her new name.
It was during the filming of I Wanted Wings that Lake developed her signature look. Lake's long blonde hair accidentally fell over her right eye during a take and created a "peek-a-boo" effect. "I was playing a sympathetic drunk, I had my arm on a table ... it slipped ... and my hair – it was always baby fine and had this natural break – fell over my face ... It became my trademark and purely by accident", she recalled. I Wanted Wings was a big hit. The hairstyle became Lake's trademark and was widely copied by women. Even before the film came out, Lake was dubbed "the find of 1941". However, Lake did not think this meant she would have a long career and maintained her goal was to be a surgeon. "Only the older actors keep on a long time ... I don't want to hang on after I've reached a peak. I'll go back to medical school", she said.
Lake in her first starring role, opposite Joel McCrea in Sullivan's Travels (1941). Paramount announced two follow-up movies, China Pass and Blonde Venus. Instead, Lake was cast in Preston Sturges's Sullivan's Travels with Joel McCrea. She was six months pregnant when filming began. Paramount put Lake in a thriller, This Gun for Hire (1942), with Robert Preston as her love interest. However, she shared more scenes with Alan Ladd; the two of them were so popular together that they would be reteamed in lead roles for three more films. Both had cameos in Star Spangled Rhythm (1942), an all-star Paramount film.
Lake was meant to be reunited with McCrea in another comedy, I Married a Witch, (also 1942) produced by Sturges and directed by René Clair, but McCrea refused to act with her again, reportedly saying, "Life's too short for two films with Veronica Lake". Production was delayed, enabling Lake to be reunited with Ladd in The Glass Key (again 1942), replacing Patricia Morison. The male lead in I Married a Witch was eventually played by Fredric March and the resulting movie, like The Glass Key, was successful at the box office. René Clair, the director of I Married a Witch, said of Lake, "She was a very gifted girl, but she didn't believe she was gifted." Lake was meant to co-star with Charles Boyer in Hong Kong for Arthur Hornblow, but it was not made.[21] She received acclaim for her part as a suicidal nurse in So Proudly We Hail! (1943). At the peak of her career, she earned $4,500 a week. Lake had a complex personality and acquired a reputation for being difficult to work with. Eddie Bracken, her co-star in Star Spangled Rhythm, in which Lake appeared in a musical number, was quoted as saying, "She was known as 'The Bitch' and she deserved the title." However, Lake and McCrea did make another film together, Ramrod (1947). During filming of The Blue Dahlia (1946), screenwriter Raymond Chandler referred to her as "Moronica Lake".
During World War II, Lake changed her trademark peek-a-boo hairstyle at the urging of the government to encourage women working in war industry factories to adopt more practical, safer hairstyles. Although the change helped to decrease accidents involving women getting their hair caught in machinery, doing so may have damaged Lake's career. She also became a popular pin-up girl for soldiers during World War II and traveled throughout the United States to raise money for war bonds.
Lake's career faltered with her unsympathetic role as Nazi spy Dora Bruckman in The Hour Before the Dawn (1944), shot in mid 1943. Scathing reviews of The Hour Before the Dawn included criticism of her rather unconvincing German accent.[citation needed] She had begun drinking more heavily during this period, and a growing number of people refused to work with her. Lake had a number of months off work, during which time she lost a child and was divorced. In early 1944 she was brought back in Bring On the Girls (1945), Lake's first proper musical, although she had sung in This Gun for Hire and Star Spangled Rhythm. She was teamed with Eddie Bracken and Sonny Tufts. The movie was not a financial success.
In June 1944, Lake appeared at a war bond drive in Boston, where her services as a dishwasher were auctioned off. She also performed in a revue, with papers saying her "talk was on the grim side". Hedda Hopper later claimed this appearance was responsible for Paramount giving her the third lead in Out of This World (1945), supporting Diana Lynn and Bracken, saying "Lake clipped her own wings in her Boston bond appearance ... It's lucky for Lake, after Boston, that she isn't out of pictures". Lake had a relatively minor role in a film produced by John Houseman, Miss Susie Slagle's (also 1945), co starring Sonny Tufts; Lake was top billed but her part was smaller than Joan Caulfield's. In November 1944 she made a third film with Bracken, Hold That Blonde (1945). She liked this part saying "it's a comedy, rather like what Carole Lombard used to do ... It represents a real change of pace".
Lake then made a second film produced by John Houseman, The Blue Dahlia (1946), which reunited her with Ladd. While waiting for the films to be released in 1945, she took stock of her career, claiming, "I had to learn about acting. I've played all sorts of parts, taken just what came along regardless of high merit. In fact, I've been a sort of general utility person. I haven't liked all the roles. One or two were pretty bad".
Lake expressed interest in renegotiating her deal with Paramount: The studio feels that way about it too. They have indicated they are going to fuss more about the pictures in which I appear. I think I'll enjoy being fussed about ... I want this to be the turning point and I think that it will. I am free and clear of unpleasant characters, unless they are strongly justified. I've had a varied experience playing them and also appearing as heroines. The roles themselves haven't been noteworthy and sometimes not even especially spotlighted, but I think they've all been beneficial in one way or another. From here on there should be a certain pattern of development, and that is what I am going to fight for if necessary, though I don't believe it will be because they are so understanding here at Paramount. Since So Proudly We Hail only The Blue Dahlia had been a hit. She made her first film outside Paramount since she became a star, a Western, Ramrod (1947), directed by her then-husband Andre DeToth, which reunited her with Joel McCrea, despite his earlier reservation. It was successful.
Back at her home studio she had a cameo in Variety Girl (1947) then was united with Ladd for the last time in Saigon (1948), in which she returned to her former peek-a-boo hairstyle; the movie was not particularly well received. Neither was a romantic drama, Isn't It Romantic (also 1948) or a comedy The Sainted Sisters (1948). In 1948 Paramount decided not to renew Lake's contract. Lake moved to 20th Century Fox to make Slattery's Hurricane (1949), directed by DeToth. It was only a supporting role and there were not many other offers.
In 1950 it was announced she and DeToth would make Before I Wake (from a suspense novel by Mel Devrett) and Flanagan Boy. Neither was made. She appeared in Stronghold (1951), which she later described as "a dog", an independent production from Lippert Pictures shot in Mexico. She later sued for unpaid wages on the film. Lake and DeToth filed for bankruptcy that same year. The IRS later seized their home for unpaid taxes. On the verge of a nervous breakdown and bankrupt, Lake ran away, left DeToth, and flew alone to New York. "They said, 'She'll be back in a couple of months,'" recalled Lake. "Well I never returned. Enough was enough already. Did I want to be one of the walking dead or a real person?" She performed in summer stock theatre and in stage roles in England. In October 1955, she collapsed in Detroit, where she had been appearing on stage in The Little Hut.