In the award in the Civil Aeronautics Board's Seven States Area Case, Ozark Airlines’ Air Mail Route 107 was expanded on March 1, 1959 by the spur extension of former Segment 8 from Fort Dodge, Iowa to Omaha, Nebraska, and the addition of six new segments: 10 to 15 inclusive. Segment 10 extended from Davenport / Moline to Minneapolis / Saint Paul; Segment 11 from Des Moines to Minneapolis / Saint Paul; Segment 12 from Des Moines to Chicago; Segment 13 from Des Moines to Milwaukee; Segment 14 from Saint Louis to Quincy / Hannibal; and Segment 15 from Chicago to Kansas City. 

This cover was carried on the inaugural Air Mail Route 107 flight from the Saint Louis, Missouri Airport Mail Facility to Quincy, Illinois (where it was backstamped).

On October 26, 1986, Ozark Airlines was merged into the operations of Trans World Airlines. TWA had been Ozark Airlines’ primary competitor at its Saint Louis hub. At the time of the acquisition, the two carriers operated almost three-quarters of the flights to and from that airport.

In January 2001, TWA filed for a third and final bankruptcy and was acquired by American Airlines. American Airlines laid off many former TWA employees after the September 11, 2001 attacks. TWA continued to exist as an LLC under American Airlines until July 1, 2003. American Airlines closed the St. Louis hub later that year.