Air Mail Route 25 extended the previous Chicago to Cincinnati service provided by Contract Air Mail Route 24 with the addition of a segment from Cincinnati to Washington, DC, via Charleston, West Virginia.

This cover was carried on the June 10, 1934 inaugural Air Mail Route 25 flight from Charleston, West Virginia to Washington, DC and is listed in the Contract Air Mail Flights (CAM) section of The American Air Mail Catalogue as 24E4.

The Charleston Postmaster autographed the cover.