Apollo Flight Crew:

• Tom Hanks as Apollo 13 Commander Jim Lovell
• Kevin Bacon as Apollo 13 backup Command Module Pilot Jack Swigert
• Bill Paxton as Apollo 13 Lunar Module Pilot Fred Haise

Mission Control:

• Gary Sinise as Apollo 13 prime Command Module Pilot Ken Mattingly
• Ed Harris as White Team Flight Director Gene Kranz
• Chris Ellis as Director of Flight Crew Operations Deke Slayton
• Joe Spano as "NASA Director", a composite character loosely based on Chris Kraft
• Marc McClure as Black Team Flight Director Glynn Lunney
• Clint Howard as White Team Electrical, Environmental and Consumables Manager (EECOM) Sy Liebergot
• Ray McKinnon as White Team Flight Dynamics Officer Jerry Bostick
• Todd Louiso as White Team Flight Activities Officer
• Loren Dean as EECOM John Aaron
• Jim Meskimen as White Team Telemetry, Electrical, EVA Mobility Unit Officer (TELMU)
• David Andrews as Apollo 12 Commander Pete Conrad
• Christian Clemenson as Flight Surgeon Dr. Charles Berry
• Ben Marley as Apollo 13 backup Commander John Young
• Brett Cullen as Capsule Communicator (CAPCOM) 1
• Ned Vaughn as CAPCOM 2
• Carl Gabriel Yorke as SIM (Simulator) 1
• Arthur Senzy as SIM 2

Civilians:

• Kathleen Quinlan as Marilyn Gerlach Lovell, Jim's wife
• Xander Berkeley as Henry Hurt, a fictional NASA Office of Public Affairs staff member^[8]
• Tracy Reiner as Haise's wife Mary
• Mark Wheeler as Neil Armstrong, Apollo 11 Commander
• Larry Williams as Buzz Aldrin, Apollo 11 Lunar Module Pilot
• Mary Kate Schellhardt as Lovell's older daughter Barbara
• Max Elliott Slade as Lovell's older son James (Jay), who attended military school at the time of the flight
• Emily Ann Lloyd as Lovell's younger daughter Susan
• Miko Hughes as Lovell's younger son Jeffrey