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The Spiral Staircase is a 1946 American psychological horror film[5] directed by Robert Siodmak and starring Dorothy McGuire, George Brent, and Ethel Barrymore. Set over the course of one evening, the film follows a mute young woman in an early-20th century Vermont town who is stalked and terrorized in a rural mansion by a serial killer targeting women with disabilities. Gordon Oliver, Rhonda Fleming, and Elsa Lanchester appear in supporting roles. It was adapted for the screen by Mel Dinelli from the novel Some Must Watch (1933) by Ethel Lina White.

The project originated with producer David O. Selznick, who purchased the rights to White's novel, intending to cast Ingrid Bergman in the lead role. Selznick subsequently sold the rights to RKO Radio Pictures, who commenced production and cast McGuire in the lead. Filming took place at the RKO Radio Pictures studio lot in Los Angeles between August and October 1945.