Noted musicians who played in his band included Artie Shaw, Xavier Cugat, Jimmy Dorsey, Tommy Dorsey, Bob Effros, Mike Mosiello, Fred Lowery, Joe Tarto and Glenn Miller.[1] He also featured singers Keller Sisters and Lynch, Betty Hutton, and Marion Hutton. Lopez's longtime drummer was the irreverent Mike Riley, who popularized the novelty hit "The Music Goes Round and Round".
Lopez's flamboyant style of piano playing influenced such later musicians as Eddy Duchin and Liberace.
In 1941, Lopez's Orchestra began a residency at the Taft Hotel in Manhattan that would last 25 years.[1]
In the early 1950s, Lopez along with Gloria Parker hosted a radio program broadcast from the Taft Hotel called Shake the Maracas in which audience members competed for small prizes by playing maracas with the orchestra.
In 1960 he published his autobiography Lopez Speaking.[7] Vincent Lopez died at the Villa Maria nursing home in North Miami, Florida, on September 20, 1975