After considerable delay, service over Segment 5 (Saint Louis to Memphis) was inaugurated on January 9, 1951. This Segment operated from Saint Louis to Memphis via Cape Girardeau, Cairo, Paducah, Dyersburg, and Jackson. 

This cover was carried on the inaugural Air Mail Route 107 flight from Cairo, Illinois to Memphis, Tennessee (where it was backstamped) and is listed in the Contract Air Mail Flights (CAM) Section of The American Air Mail Catalogue as 107SE19.

The Cairo Postmaster autographed the cover.

On October 26, 1986, Ozark Airlines was merged into the operations of Trans World Airlines. TWA had been Ozark Airlines’ primary competitor at its Saint Louis hub. At the time of the acquisition, the two carriers operated almost three-quarters of the flights to and from that airport.

In January 2001, TWA filed for a third and final bankruptcy and was acquired by American Airlines. American Airlines laid off many former TWA employees after the September 11, 2001 attacks. TWA continued to exist as an LLC under American Airlines until July 1, 2003. American Airlines closed the St. Louis hub later that year.