Guarana contains caffeine. Caffeine works by stimulating the central nervous system(CNS), heart, and muscles. Guarana also contains theophylline and theobromine, which are chemicals similar to caffeine.
https://www.healthline.com/nutrition/guarana-benefits#section1
Guarana is loaded with compounds that have antioxidant properties.
These include caffeine, theobromine, tannins, saponins and catechins
In fact, guarana has an antioxidant profile similar to that of green tea
Antioxidants are important because they neutralize potentially harmful molecules called free radicals. These molecules can interact with parts of your cells and cause damage linked to aging, heart disease, cancers and other diseases
Test-tube studies have found that guarana’s antioxidant properties may combat cancer cell growth and reduce heart disease risk and skin aging
Guarana is best known as an ingredient in popular energy drinks.
It’s an excellent source of caffeine, which helps you maintain focus and mental energy.
In fact, guarana seeds may contain four to six times more caffeine than coffee beans
Caffeine works by blocking the effects of adenosine, a compound that helps your brain relax. It binds to adenosine receptors, preventing them from being activated
A study found that people who took a guarana-containing vitamin supplement felt less fatigued while completing several tests, compared to those who took a placebo
Interestingly, studies also show that guarana can reduce mental fatigue due to cancer treatment, without significant side effects
Research has shown that guarana may improve your ability to learn and remember.
One study looked at the effects of different doses of guarana on mood and learning. Participants received either no guarana, 37.5 mg, 75 mg, 150 mg or 300 mg
People who received either 37.5 mg or 75 mg of guarana achieved the highest test scores. Since low doses of guarana provide low doses of caffeine, it’s believed that other compounds in guarana aside from caffeine may be partially responsible
Another study compared guarana to ginseng, another brain-boosting compound.
Although both guarana and ginseng improved memory and test performance, people who received guarana paid more attention to their tasks and completed them faster
Furthermore, animal studies have shown that guarana can improve memory
It’s estimated that one in three American adults is obese (20).
Obesity is a growing concern, as it has been linked to many chronic diseases, including heart disease, type 2 diabetes and cancer
Interestingly, guarana may have properties that help promote weight loss.
First, guarana is a rich source of caffeine, which may boost your metabolism by 3–11% over 12 hours. A faster metabolism means your body burns more calories at rest
What’s more, test-tube studies have found that guarana may suppress genes that aid fat cell production and promote genes that slow it down
However, guarana’s effects on fat cell production in humans remain unclear.
Guarana has been used for centuries as a natural stomach tonic to treat digestive problems like chronic diarrhea and constipation
It may have anti-diarrhea properties because it’s rich in tannins, or plant-based antioxidants.
Tannins are known for their astringency, which means they can bind and contract tissue. This allows tannins to waterproof the walls of your digestive tract, restricting how much water is secreted into your bowels
On the other hand, guarana is rich in caffeine, which may act as a natural laxative.
Caffeine stimulates peristalsis, a process that activates contractions in the muscles of your intestines and colon. This may relieve constipation by pushing contents to the rectum
Low doses of guarana do not provide much caffeine, so they are more likely to have an anti-diarrhea effect. High doses provide more caffeine and may have laxative effects.
Heart disease is responsible for one in four deaths in America
Guarana may reduce the risk of heart disease in two ways.
First, the antioxidants in guarana appear to aid blood flow and may prevent blood clots
Second, studies have shown that guarana may decrease the oxidation of “bad” LDL cholesterol. Oxidized LDL cholesterol can contribute to plaque build-up in your arteries.
In fact, adults who consume guarana may have up to 27% less oxidized LDL than adults of a similar age who don’t eat this fruit
However, most research on the connection between heart health and guarana comes from test-tube studies. More human-based studies are needed before recommendations can be made.
Historically, guarana was used by Amazonian tribes as a pain reliever.
The pain-relieving properties of guarana are due to its high caffeine content.
Caffeine plays a role in pain management, as it binds and blocks adenosine receptors.
Two of these receptors — A1 and A2a — are involved in stimulating feelings of pain
When caffeine binds to these receptors, it can reduce sensations of pain.
This is one reason why caffeine is commonly found in many over-the-counter pain relief medications. Studies have shown it can significantly enhance their effects
Due to its strong antioxidant and antimicrobial properties, guarana is popular in the cosmetics industry as an ingredient in anti-aging creams, lotions, soaps and hair products.
Moreover, its caffeine content aids blood flow to the skin
Test-tube studies have shown that the antioxidants in guarana may significantly reduce age-related skin damage (9).
What’s more, animal studies found that guarana-containing cosmetics may reduce sagging in your cheeks, improve skin tightness and minimize wrinkles around your eyes
Cancer is a disease characterized by the uncontrolled growth of cells.
Animal and test-tube studies have shown that guarana may protect against DNA damage, suppress cancer cell growth and even trigger cancer cell death
One study in mice found that those fed guarana had 58% fewer cancer cells and nearly a five-fold increase in cancer cell death, compared to mice that did not receive guarana
Another test-tube study found that guarana suppressed the growth of cancer cells in the colon, as well as stimulated their death
It’s believed that the potential anti-cancer properties of guarana stem from its content of xanthines, which are compounds that are similar to caffeine, theobromine and catechins.
That said, though the results of test-tube and animal studies are promising, more human-based research is needed.
Guarana contains many compounds that may inhibit or kill harmful bacteria.
One of these bacteria is Escherichia coli (E. coli), which lives in the intestines of humans and animals.
Most E. coli bacteria are harmless, but some can cause diarrhea or illness
Studies have also found that guarana can suppress the growth of Streptococcus mutans (S. mutans), a bacteria that can cause dental plaques and tooth decay
It’s believed that the combination of caffeine and plant-based compounds like catechins or tannins is responsible for guarana’s antibacterial effects
It’s common for eyesight to progressively worsen with age.
Things like sunlight, poor diet and certain lifestyle choices like smoking can wear down your eyes over time and increase your risk of eye-related disorders
Guarana contains compounds that fight oxidative stress, a major risk factor for age-related eye disorders like macular degeneration, cataracts and glaucoma
One study found that people who consumed guarana regularly had better self-reported vision than people who consumed it sparingly or not at all
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