On completion, Massachusetts was sent to support Operation Torch, the invasion of French North Africa, in November 1942. There, she engaged in an artillery duel with the incomplete French battleship Jean Bart and neutralized her. Massachusetts thereafter transferred to the Pacific War for operations against Japan; she spent the war primarily as an escort for the fast carrier task force to protect the aircraft carriers from surface and air attacks. In this capacity, she took part in the Gilbert and Marshall Islands campaign in 1943 and early 1944 and the Philippines campaign in late 1944 and early 1945. Later in 1945, the ship supported Allied forces during the Battle of Okinawa and thereafter participated in attacks on Japan, including bombarding industrial targets on Honshu in July and August.

After the war, Massachusetts returned to the United States and was decommissioned and assigned to the Atlantic Reserve Fleet in 1947. She remained out of service until 1962, when she was stricken from the Naval Vessel Register. Three years later, she was transferred to the Massachusetts Memorial Committee and preserved as a museum ship at Battleship Cove in Fall River, Massachusetts. Some material was removed in the 1980s to reactivate the Iowa-class battleships, but the ship otherwise remains in her wartime configuration.