Autore: Israa A. Mahmud,Hayder Al-Domi
Formato: Copertina flessibile
Pagine: 116
Data Pubblicazione: 2013-02-18
Edizione: 1
Lingua: English
Descrizione:
Obesity has emerged as one of the major public health concerns of the 21th century. High intake of energydense food and inactivity markedly contributes to the expansion of this problem. Therefore, identifying effective measures is crucial to combat this epidemic. Exercise is one of the common recommended remedy for obese persons to prevent weight gain and to improve metabolic profile. Recently, it has been speculated that the impact of exercise on body weight homeostasis is mediated by changes in the plasma levels of appetiteregulating hormones, and glucagonlike peptide1 (GLP1) is one of these hormones. Some studies observed lower postprandial levels of GLP1 in some obese individuals than in lean controls, which may suggest deterioration in satiety responses, and glucose and lipid metabolism. Therefore, restoration of GLP1 action by exercise and exendin4, a longacting receptor agonist of GLP1 that has anorexigenic and metabolicimproving properties similar to GLP1, may ameliorate this disorder. This book examines whether exercise and exendin4 can modulate postprandial dysmetabolism associated with obesity, and whether this effect is independent or synergistic.