Autore: Mukesh C. Sharma,Smita Sharma
Formato: Copertina flessibile
Pagine: 100
Data Pubblicazione: 2014-05-23
Edizione: 1
Lingua: English
Descrizione:
Hypertension has become one of the most important preventable causes for premature morbidity and mortality worldwide. To identify novel and potent antihypertensive ligands, initially 2DQSAR, Group based QSAR, kNN based 3DQSAR and pharmacophore were generated using namely, a series of triazolinone, quinazolinone, and benzimidazole derivatives of as Angiotensin II AT1 Receptor. In conclusion, the models developed to predict the structural features of substituted analogues angiotensin II receptor antagonists, reveals useful information about the structural features requirement for the molecule.