Publisher Description

In this book, the author has given a comprehensive description of 101 medical autopsy cases (48 adult and 53 pediatric) with their complete clinical and pathological details. Each case is unique and has been discussed in a simple, practical, straightforward, but comprehensive manner.Comprehensive compilation of 101 medical autopsy cases (48 adult and 53 pediatric - children, infants, neonates, stillbirths and terminated fetuses) in a case based manner. First book in the world literature to have compiled medical autopsy cases with complete clinical and pathological details, and agallery of gross and microscopic pictures with review of literature.The cases have been grouped in the following order: hematologic disorders, malignancies, infections, hepatobiliary and pancreatic disorders, cardiovascular system, systemic vasculitides, primary renal mucormycosis, histiocytosis, primary immunodeficiency, infantile nephrotic syndromes, congenital heart disease, storage disorder and pediatric renal cystic disease (developmental/genetic/syndromes).Introduction to medical autopsy, systemic vasculitides, tubercular meningitis and pediatric renal cystic diseases are added for better understanding. Each autopsy case is a complete journey of the patient/deceased and has been concisely discussed under the following headings: title, highlights of the case, clinical details, investigations, clinical diagnosis, complete histopathological or autopsy findings with a gallery of gross and microscopic photographs (3,000 plus), final autopsy diagnosis, review of literature, commentary index case, take home message and suggested reading or references.This book will be a great teaching material for the pathologists, medical physicians, pediatricians, neonatologists, obstetricians, radiologists along with undergraduates/postgraduates students.

Table of Contents

Introduction
Medical Autopsy: The Strongest Teaching Tool in Medicine
Section 1: Hematological Disorders—Adult Cases
Case 1: Mantle Cell Lymphoma, Presenting with Florid Cutaneous Lesions, with Common Variant Morphology in the Nodal/Extranodal Sites and Blastoid Morphology in the Peripheral Blood:PM 25983
Case 2: Primary Myelofibrosis, Cellular Phase with Formation of Sclerosing Extramedullary Hematopoietic Tumors: PM 27873
Case 3: Primary Myelofibrosis, Cellular Phase with Extensive Extramedullary Hematopoiesis and Transformation into Acute Leukemia: PM 23618
Case 4: Hepatosplenic T-cell Lymphoma: PM 23096
Case 5: Acute Promyelocytic Leukemia with Early Death due to Disseminated Intravascular Coagulation and Right Temporal Lobe Hemorrhage: PM 26880
Case 6: Acute Promyelocytic Leukemia with Differentiation Syndrome: PM 17959
Case 7: Chronic Lymphatic Leukemia, Post-Bone Marrow Transplantation with Recurrence, Massive Lymphadenopathy and Hemophagocytosis: PM 21710
Case 8: Symptomatic Plasma Cell Myeloma with Primary Systemic Amyloidosis Showing a Predominant Involvement of the Heart and Gastrointestinal Tract: PM 19667
Section 2: Malignancy—Adult Cases
Case 9: Microscopic/Occult Testicular Seminoma with Germ Cell Neoplasia in situ and Widespread Nonseminomatous Metastasis in a Young Male: PM 14170
Case 10:Malignant Teratoma, Primary Pulmonary, Containing Yolk Sac tumor, Associated with Hematologic Neoplasia: PM 13633
Case 11:Young Male with Metastasis: Do not Waste Time—Look for the Primary in the Testes: PM 19388
Case 12: Occult, Peripheral, Mucin-secreting Adenocarcinoma of Lung with Florid Meningeal Carcinomatosis along with Thrombotic Microangiopathy and Disseminated Intravascular Coagulation, Leading to Bilateral Renal Infarction: PM 26226
Case 13: Young Male with Occult, Diffuse Type, Mucin-secreting Adenocarcinoma of the Stomach with Extensive Lymphangitic Carcinomatosis, Presenting with Deep Vein Thrombosis and Pulmonary Embolism: PM 21829
Section 3: Infections—Adult Cases
Case 14: Amebic Ileocolitis, Perforation and Liver Abscess: PM 18836
Case 15: Cerebral Toxoplasmosis in a Human Immunodeficiency Virus Positive Patient: PM 19210
Case 16: Pulmonary Hyalinizing Granuloma with Recent Onset Cryptococcal Meningoencephalitis in an Immunocompetent Male: PM 21122
Case 17: Leptospirosis with Multiorgan Involvement: PM 22793
Case 18: Silicotuberculosis: PM 26075
Case 19: Rabies Meningoencephalitis, Post-Pet Dog Bite: PM 27786
Section 4: Hepatobiliary and Pancreatic Disorders—Adult Cases
Case 20: Extrahepatic Portal Venous Obstruction due to Cavernomatous Transformation of Portal Vein and Portal Cavernoma Cholangiopathy: PM 22260
Case 21: Chronic Budd-Chiari Syndrome with Mesoatrial Shunt, Venocentric Cirrhosis, Hepatocellular Carcinoma Infiltrating into the Hepatic Duct Causing Obstruction and Hemobilia: PM 27800
Case 22: Acute on Chronic Pancreatitis Leading to Portal Vein Pyemia, with Multiple Liver Abscesses and Life-threatening Sepsis Shock: PM 25975
Case 23: Lipomatous Pseudohypertrophy of the Pancreas with Polyglandular Autoimmune Syndrome Type II and Inflammatory Myopathy: PM 22590
Case 24: Young Male with Early Onset Micronodular Cirrhosis due to Synergistic Hepatotoxic Effect of Alcohol and Hepatitis C Virus Infection along with Cryoglobulinemic Vasculitis: PM 27791
Case 25: Diffuse Hepatocellular Carcinoma Arising in a Setting of Mixed Nodular Cirrhosis, Hepatitis C Virus and Alcohol Related: PM 26695
Case 26:Acute Liver Failure and Encephalopathy in a Case of Dengue Shock Syndrome: PM 25035
Case 27: Postpartum, Hyperacute, Fulminant Hepatic Failure due to Hepatitis E Virus: PM 26595
Case 28: Sporadic, Hepatitis E-related Massive Hepatic Necrosis in a Young Female: PM 26254
Case 29: A Classical Case of Wilson's Disease with Hepatic and Neuropsychiatric Manifestations: PM 26195
Section 5: Cardiovascular System—Adult Cases
Case 30: Silent Healed Myocardial Infarction and its Complications—Infarct Expansion, Mural Thrombosis, Aneurysm Formation, Extensive Arterial Embolization, Deep Vein Thrombosis and Subsequent Fatal Venous Thromboembolism: PM 21817
Case 31: Coexistence of Acute-on-Chronic Rheumatic Heart Disease and Acute Poststreptococcal Glomerulonephritis: PM 21119
Case 32: A Classical Case of Marfan Syndrome with Aortic Root Dilatation, Aneurysm of the Ascending Aorta and Acute Aortic Dissection: PM 22554
Case 33: Adult Tetralogy of Fallot with Tricuspid Valve Infective Endocarditis and Thromboembolic Botryomycotic Cerebral Abscess: PM 26941
Case 34: Cocaine-induced Vasculopathy Leading to Cardiomyopathy, Renal Infarcts, Gangrene of Digits with Autoamputation: PM 23445
Case 35: Aftermath of Hypertension in a Middle-aged Male—Intraparenchymal Brain Hemorrhage, Pontine and Thalamic: PM 26485
Section 6: Systemic Vasculitides—Adult and Pediatric Cases
Systemic Vasculitides—Introduction
Small Vessel Vasculitides
Case 36: Renal Limited Microscopic Polyangiitis: PM 13127
Case 37: Microscopic Polyangiitis, ANCA Negative, with Florid Glomerulitis and Granulomatous Glomerulonephritis: PM 15649
Case 38: Microscopic Polyangiitis in a Child: PM 16450
Case 39: Microscopic Polyangiitis, ANCA Negative, Clinically Mimicking Granulomatosis with Polyangiitis (Wegener's Granulomatosis) and Presenting with a Breast Mass: PM 18473
Case 40: Microscopic Polyangiitis—Chronic Phase: PM 18987
Case 41: Microscopic Polyangiitis with Acute Vasculitis of Small, Medium and Large-sized Arteries: PM 20415
Case 42: p-ANCA Positive Classic Polyarteritis Nodosa: PM 24277
Case 43: Takayasu's Aortoarteritis, Pulmonary Hypertension, and Pulmonary Capillary Hemangiomatosis: PM 14993
Case 44: Takayasu Aortoarteritis, Presenting with Pulmonary Arterial Hypertension Secondary to Extensive Involvement of Right Pulmonary Artery: PM 25988
Case 45: Granulomatosis with Polyangiitis (Wegener's Granulomatosis) with Left Foot Gangrene and Right Hemiplegia: PM 14106
Case 46: Granulomatosis with Polyangiitis—Wegener's Granulomatosis, Presenting as an Anterior Mediastinal Mass: PM 18613
Case 47: Granulomatosis with Polyangiitis, i.e Wegener's with Multiple Pulmonary Nodules and Total Splenic Necrosis: PM 21594
Case 48: c-ANCA Positive, Nonreactive, Disseminated Tuberculosis with Pulmonary and Mesenteric Vasculitis: PM 14513
Section 7: Primary Renal Mucormycosis—Adult and Pediatric Cases
Case 49: Isolated Bilateral Renal Mucormycosis with Contiguous Spread to the Adrenals, Mesentery, Pancreas and Colon in an Apparently Immunocompetent Adult: PM 27250
Case 50: Primary Bilateral Renal Mucormycosis in an Apparently Immunocompetent Child: PM 22863
Section 8: Histiocytosis—Pediatric and Adult Cases
Case 51: Primary/Familial Hemophagocytic Lymphohistiocytosis with Extensive Involvement of the Brain: PM 20788
Case 52: Langerhans Cell Histiocytosis Presenting as an Anterior Mediastinal Mass: PM 21476
Case 53: Macrophage Activation Syndrome—A Fatal Complication of Systemic Onset Juvenile Idiopathic Arthritis: PM 26202
Case 54: Epstein–Barr Virus-associated Secondary Hemophagocytic Lymphohistiocytosis—
A Rare Complication: PM 21703
Section 9: Primary Immunodeficiency—Pediatric Cases
Case 55: Disseminated Bacillus Calmette–Guérin Infection in a Case of Severe Combined
Immunodeficiency: PM 22931
Case 56: Chronic Granulomatous Disease of Childhood: PM 24170
Case 57: Disseminated Nonreactive Tuberculosis, PCR-Proven Dual Positivity for Mycobacterium Tuberculosis and Abscessus ? Mendelian Susceptibility to Mycobacterial Disease: PM 25174
Section 10: Infantile Nephrotic Syndrome
Case 58: Congenital Nephrotic Syndrome of the Finnish Type: PM 23777
Case 59: Infantile Nephrotic Syndrome—Diffuse Mesangial Sclerosis in a 10-Month-Old Male Child: PM 26462
Section 11: Infections—Pediatric Cases
Case 60: Disseminated Congenital Cytomegalovirus Infection with Islet Cell Hyperplasia as the Cause of Persistent Hypoglycemia in a Neonate: PM 23822
Case 61: Congenital Tuberculosis: An Underdiagnosed Entity: PM 24753
Case 62: Disseminated Cryptococcomas Mimicking Disseminated Malignancy, with Hepatic Dysfunction as the Initial Manifestation, in an Immunocompetent Child: PM 25744
Introduction to Tubercular Meningitis
Case 63: Catastrophic Posterior Circulation Tubercular Arteritis with Infarcts and Cortical
Venous Thrombosis—A Rare Co-existence: PM 26344
Case 64: Child with Disseminated Miliary Tuberculosis, Tubercular Meningitis with
Extensive Arteritis, Infarction and Ischemic Hepatitis: PM 25901
Case 65: Disseminated Cryptococcal Infection in an HIV-positive Child: PM 23563
Section 12: Cardiovascular System—Pediatric Case
Case 66: Transposition of Great Arteries: PM 24027
Section 13: Hematological Disorders—Pediatric Cases
Case 67: Child with Acute Lymphoblastic Leukemia on Induction Therapy with Febrile
Neutropenia and Disseminated Aspergillus Infection: PM 25927
Case 68: Myeloid Sarcoma of Lacrimal Sac as the First Manifestation of AML-M1 with Acute Diffuse Colorectal Neutropenic Colitis in a Child: PM 23395 576
Section 14: Storage Disorder
Case 69: Niemann–Pick Type B Presenting with Massive Splenohepatomegaly and Hypertensive Crisis in a 12-year-old Child: PM 27096
Section 15: Pediatric Renal Cystic Disease (Developmental/Genetic/Syndromes)
Pediatric Cystic Disease (Developmental/Genetic) of Kidney—Introduction
Section 15A: Renal Dysplasia
Case 70: Recurrent Bilateral Multicystic Dysplastic Kidneys, Consistent with Hereditary
Renal Adysplasia: PM 20505
Case 71: Symmetrically Enlarged, Solid Dysplastic Kidneys with Intrauterine Growth
Retardation: PM 24340
Case 72: Multicystic Dysplastic Kidneys with Dilated Ureters and Hypertrophied Urinary
Bladder Leading to Obstructed Labor and Uterine Rupture: PM 26207
Case 73-74: Renal Hypodysplasia: PM 19521, PM 25711 619
Nandita Bharadwaj Kakkar
Case 75: Bilateral Renal Agenesis: PM 24019
Case 76-80: Unilateral Renal Malformation: PM 22428, PM 22393, PM 26428, PM 26291, PM 26824
Case 81: Segmental Renal Dysplasia with Duplex Kidney and Ureterocele: PM 19965
Section 15B: Posterior Urethral Valve
Case 82-83: Posterior Urethral Valve Leading to Congenital Hydroureteronephrosis and
Hypertrophied Urinary Bladder: PM 18485, PM 26118
Section 15C: Renal Hypoplasia
Case 84: Neonate with Bilateral Simple Renal Hypoplasia, Lung Hypoplasia and Hydrocephalous: PM 27245
Case 85: Bilateral Simple Renal Hypoplasia, Cystic Periventricular Leukomalacia with Hydrocephalus ex vacuo in Surviving Twin, after death of Monochorionic Co-twin: PM 25677
Case 86: Segmental Hypoplasia (Ask-Upmark Kidney): S-14525/2008
Section 15D: Genetic Disorders
Case 87: A Classical Case of Autosomal Recessive Polycystic Kidney Disease: PM 22879
Case 88: Autosomal Dominant Polycystic Kidney Disease with Cyst Infection: PM 22828
Section 15E: Glomerulocystic Kidney Disease
Case 89: Co-existing Glomerulocystic Kidney Disease and Renal Tubular Dysgenesis with Late Onset Oligohydramnios and Renal Failure at D2 of Life: PM 28154
Case 90: Glomerulocystic Kidney Associated with Posterior Urethral Valve— A Rare Association: PM 28255
Section 15F: Syndromes
Case 91-92: Meckel–Gruber Syndrome: PM 20070, PM 26190
Case 93-94: Prune Belly Syndrome Leading to a Markedly Distended Urinary Bladder and
Hydroureteronephrosis: PM 23424, PM 25509
Case 95: Sirenomelia with Bilateral Renal Agenesis and Multiple Other Malformations: PM 27025
Section 16: Liver Disorders—Pediatric Cases
Case 96: Coexistence of Duarte 2 Variant of Galactosemia with Niemann–Pick Disease Type B, in an Infant: PM 23108
Case 97: A Classical Case of Galactosemia: PM 23869
Case 98: Galactosemia, Double Heterozygous for N314D and Q188R Mutations, with
Micronodular Cirrhosis and Absence of Steatosis: PM 25342
Case 99: A Case of Galactosemia, Double Heterozygous for Q188R and E308K Mutations with Early Neonatal Acute Liver Failure: PM 25552
Case 100: Neonate with Hemolytic Disease of Newborn (Due to Rh Isoimmunization—for both Rh-D Antigen and Rh-C Antigen), Conjugated Hyperbilirubinemia, and Associated Nonsyndromic Paucity of Intrahepatic Bile Ducts: PM 27937
Case 101: Indian Childhood Cirrhosis: PM 24527
Abbreviations
Index

Details