Alka-Seltzer Time (aka The Alka-Seltzer Show) was a 15-minute radio series broadcast weekdays on both CBS Radio and the Mutual Broadcasting System. This show should not to be confused with an earlier show called Alka-Seltzer Time that would later be renamed Herb Shriner Time.

The show began in 1949. It stared baritone Curt Massey along with Martha Tilton and had the original title The Curt Massey Show (sometimes advertised as The Curt Massey and Martha Tilton Show). The announcer was Ford Pearson. The show sponsor was Alka-Seltzer. The name was changed in 1952 to highlight the sponsor's product.

By 1953, the series was heard on Mutual (at 12 noon, Eastern Time) and later that same day on CBS (at 5:45pm, Eastern). Advertisements described the show as "informal song sessions" by vocalists Massey and Tilton. Tilton was often billed as "the liltin' Martha Tilton". The two singers, both Texas-born, performed with Country Washburne and His Orchestra, featuring Charles LaVere on piano.

Songs included such tunes as "Honey, I'm in Love with You", "A Gambler's Guitar", "Just to Be with You", "Moonlight", "When Love Goes Wrong", "Choo Choo Train", "I've Got Spurs that Jingle Jangle Jingle", "Put on a Bonnet", "On the Sunny Side of the Street", "Papaya Mama" and "Istanbul, Not Constantinople". There were some theme shows, such as "Go West", music from "Old Phonograph Records" and "Salute to Hawaii".

Massey and Tilton would continue to appear together during the late 1950s on such shows as Guest Star and Stars for Defense. They also teamed up to record an album, "We Sing the Old Songs" (1957). CD collections of Alka-Seltzer Time usually identify shows by the first performed song of each program. Today, Massey is best remembered as the composer (with Paul Henning) and singer of the Petticoat Junction TV show theme song.

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1 First Song - On the Sunny Side of the Street - 14:28

2 First Song - Choo Choo Train - 14:30

3 First Song - Moonlight - 14:19

4 First Song - When Love Goes Wrong - 14:26

5 First Song - I've Got Spurs That Jingle Jangle Jingle - 14:29

6 First Song - Moonlight When Shadows Fall - 14:52

7 First Song - Choo Choo Train - 14:30

8 First Song - Yaaka Hula Hickey Dula - 14:28

9 First Song - Istanbul (Not Constantinople) - 14:25

10 First Song - Get Out Those Old Records - 14:31

11 First Song - I Fall In Love With You Every Day - 14:27

12 First Song - Honey, I'm In Love With You - 14:34

13 First Song - It's Istanbul (Not Constantinople) - 14:29

14 First Song - Just To Be With You - 14:30

15 First Song - Put On A Bonnet - 14:31

16 First Song - On The Sunny Side Of The Street - 14:35

17 First Song - Papaya Mama - 14:20

18 First Song - Gambler's Guitar - 14:12

19 First Song - Collegiate - 14:22