The standard Trisquel distribution includes the MATE desktop environment and graphical user interface (GUI), and English, Spanish and 48 other localizations, 50 in total, on a 2.6 GB live DVD image. Other translations can be downloaded if an internet connection is present during installation.[11]

Trisquel Mini is an alternative to mainline Trisquel, designed to run well on netbooks and older hardware. It uses the low-resource environment LXDE and lightweight GTK+ and X Window System alternatives to GNOME and Qt-KDE applications.[12] The LXDE desktop only includes English and Spanish localizations, and can install from a 1.2 GB live DVD image.[citation needed]

Triskel is another alternative to mainline Trisquel using the KDE graphical interface, available as a 2.0 GB ISO DVD live image.[13]

Sugar is a free and open source desktop environment designed with the goal of being used by children for interactive learning. Sugar replaces the standard MATE desktop environment available with Trisquel.