Savage She-Hulk #1, published in February 1980 by Marvel Comics, is the first appearance and origin story of She-Hulk (Jennifer Walters).

The story follows Jennifer Walters, a lawyer who is shot by gangsters. In critical condition, she receives a blood transfusion from her cousin, Bruce Banner, who is also known as the Hulk. Bruce's gamma-irradiated blood transforms Jennifer into the She-Hulk, a powerful green-skinned woman with similar abilities to the Hulk, but with greater control over her emotions and intelligence.

In this issue, Jennifer grapples with her newfound abilities and appearance while seeking revenge on the criminals who shot her. She ultimately defeats them, but struggles to come to terms with her new life as the She-Hulk.

Savage She-Hulk #1 is a significant issue in Marvel Comics history, marking the introduction of a popular and enduring character. The comic has been reprinted and collected numerous times over the years, and remains a sought-after collectible for fans.