Jolie made her screen debut as a child alongside her father, Jon Voight, in Lookin' to Get Out (1982), and her film career began in earnest a decade later with the low-budget production Cyborg 2 (1993), followed by her first leading role in a major film, Hackers (1995). She starred in the critically acclaimed biographical cable films George Wallace (1997) and Gia (1998), and won an Academy Award for Best Supporting Actress for her performance in the 1999 drama Girl, Interrupted. Her starring role as the video game heroine Lara Croft in Lara Croft: Tomb Raider (2001) established her as a leading Hollywood actress. She continued her action-star career with Mr. & Mrs. Smith (2005), Wanted (2008), Salt (2010), and The Tourist (2010), and received critical acclaim for her performances in the dramas A Mighty Heart (2007) and Changeling (2008), the latter of which earned her a nomination for an Academy Award for Best Actress. Her biggest commercial success came with the fantasy picture Maleficent (2014). She is also known for her voice role in animation film series Kung Fu Panda (2008–present). Jolie has also directed and written several war dramas, namely In the Land of Blood and Honey (2011), Unbroken (2014), and First They Killed My Father (2017).

In addition to her film career, Jolie is known for her humanitarian efforts, for which she has received a Jean Hersholt Humanitarian Award and made an honorary Dame Commander of the Order of St Michael and St George (DCMG), among other honors. She promotes various causes, including conservation, education, and women's rights, and is most noted for her advocacy on behalf of refugees as a Special Envoy for the United Nations High Commissioner for Refugees (UNHCR). Jolie has undertaken over a dozen field missions globally to refugee camps and war zones; her visited countries include Sierra Leone, Tanzania, Pakistan, Afghanistan, and Sudan.

As a public figure, Jolie has been cited as one of the most powerful and influential people in the American entertainment industry. She has been cited as the world's most beautiful woman by various media outlets. Her personal life, including her relationships, marriages, and health, has been the subject of wide publicity. She is divorced from actors Jonny Lee Miller, Billy Bob Thornton and Brad Pitt. She has six children with Pitt, three of whom were adopted internationally.

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