Searle was born in Cambridge, England, where his father was a Post Office worker who repaired telephone lines. He started drawing at the age of five and left school (Central School – now Parkside School) at the age of 15. He trained at Cambridge College of Arts and Technology (now Anglia Ruskin University) for two years.

In April 1939, realizing that war was inevitable, he abandoned his art studies to enlist in the Royal Engineers. In January 1942, he was in the 287th Field Company, RE in Singapore. After a month of fighting in Malaya, he was taken prisoner along with his cousin Tom Fordham Searle, when Singapore fell to the Japanese. He spent the rest of the war as prisoner, first in Changi Prison and then in the Kwai jungle, working on the Siam-Burma Death Railway. Searle contracted both beriberi and malaria during his incarceration, which included numerous beatings, and his weight dropped to less than 40 kilograms. He was liberated in late 1945 with the final defeat of the Japanese. After the war, he served as a courtroom artist at the Nuremberg trials and later the Adolf Eichmann trial (1961).

He married the journalist Kaye Webb in 1947; they had twins, Kate and Johnny. In 1961, Searle moved to Paris, leaving his family; the marriage ended in divorce in 1967. Later he married Monica Koenig, a painter, theatre and jewellery designer. After 1975, Searle and his wife lived and worked in the mountains of Haute Provence.

Searle's wife Monica died in July 2011 and he himself died on 30 December 2011, aged 91.

Although Searle published the first St Trinian's cartoon in the magazine Lilliput in 1941, his professional career really begins with his documentation of the brutal camp conditions of his period as a prisoner-of-war of the Japanese in World War II in a series of drawings that he hid under the mattresses of prisoners dying of cholera. Searle recalled, "I desperately wanted to put down what was happening, because I thought if by any chance there was a record, even if I died, someone might find it and know what went on." But Searle survived, along with approximately 300 of his drawings. Liberated late in 1945, Searle returned to England, where he published several of the drawings in fellow prisoner Russell Braddon's The Naked Island. Another of Searle's fellow prisoners later recounted, "If you can imagine something that weighs six stone or so, is on the point of death and has no qualities of the human condition that aren't revolting, calmly lying there with a pencil and a scrap of paper, drawing, you have some idea of the difference of temperament that this man had from the ordinary human being."

Most of these drawings appear in his 1986 book, Ronald Searle: To the Kwai and Back, War Drawings 1939–1945. In the book, Searle also wrote of his experiences as a prisoner, including the day he woke up to find a dead friend on either side of him, and a live snake underneath his head:

You can’t have that sort of experience without it directing the rest of your life. I think that’s why I never really left my prison cell, because it gave me my measuring stick for the rest of my life... Basically all the people we loved and knew and grew up with simply became fertiliser for the nearest bamboo.

At least one of his drawings is on display at the Changi Museum and Chapel, Singapore, but the majority of his originals are in the permanent collection of the Imperial War Museum, London, along with the works of other POW artists. The best known of these are John Mennie, Jack Bridger Chalker, Philip Meninsky and Ashley George Old.

Searle produced an extraordinary volume of work during the 1950s, including drawings for Life, Holiday and Punch. His cartoons appeared in The New Yorker, the Sunday Express and the News Chronicle. He compiled more St Trinian's books, which were based on his sister's school and other girls' schools in Cambridge. He collaborated with Geoffrey Willans on the Molesworth books (Down With Skool!, 1953, and How to be Topp, 1954), and with Alex Atkinson on travel books. In addition to advertisements and posters, Searle drew the title backgrounds of the Sidney Gilliat and Frank Launder film The Happiest Days of Your Life.

After moving to Paris in 1961, he worked more on reportage for Life and Holiday and less on cartoons. He also continued to work in a broad range of media and created books (including his well-known cat books), animated films and sculpture for commemorative medals, both for the French Mint and the British Art Medal Society. Searle did a considerable amount of designing for the cinema, and in 1965, he completed the opening, intermission and closing credits for the comedy film Those Magnificent Men in their Flying Machines as well as the 1969 film Monte Carlo or Bust! In 1975, the full-length cartoon Dick Deadeye, or Duty Done was released. It is based on the character and songs from H.M.S. Pinafore.

Searle received much recognition for his work, especially in America, including the National Cartoonists Society's Advertising and Illustration Award in 1959 and 1965, the Reuben Award in 1960, their Illustration Award in 1980 and their Advertising Award in 1986 and 1987. Searle was appointed Commander of the Order of the British Empire in 2004.[3] In 2007, he was decorated with one of France's highest awards, the Chevalier de la Légion d'honneur, and in 2009, he received the German Lower Saxony Order of Merit.

His work has had a great deal of influence, particularly on American cartoonists, including Pat Oliphant, Matt Groening, Hilary Knight, and the animators of Disney's 101 Dalmatians.

He was an early influence on John Lennon's drawing style which featured in the books In His Own Write and A Spaniard in the Works. Anglia Ruskin University has named the Ronald Searle Award for Creativity in the Arts in his honour.

It is well known for its illustrated and often topical covers, its commentaries on popular culture and eccentric American culture, its attention to modern fiction by the inclusion of short stories and literary reviews, its rigorous fact checking and copy editing, its journalism on politics and social issues, and its single-panel cartoons sprinkled throughout each issue.

The New Yorker was founded by Harold Ross (1892–1951) and his wife Jane Grant (1892–1972), a New York Times reporter, and debuted on February 21, 1925. Ross wanted to create a sophisticated humor magazine that would be different from perceivably "corny" humor publications such as Judge, where he had worked, or the old Life. Ross partnered with entrepreneur Raoul H. Fleischmann (who founded the General Baking Company) to establish the F-R Publishing Company. The magazine's first offices were at 25 West 45th Street in Manhattan. Ross edited the magazine until his death in 1951. During the early, occasionally precarious years of its existence, the magazine prided itself on its cosmopolitan sophistication. Ross declared in a 1925 prospectus for the magazine: "It has announced that it is not edited for the old lady in Dubuque."

Although the magazine never lost its touches of humor, it soon established itself as a preeminent forum for serious fiction, essays and journalism. Shortly after the end of World War II, John Hersey's essay Hiroshima filled an entire issue. The magazine has published short stories by many of the most respected writers of the 20th and 21st centuries, including Ann Beattie, Sally Benson, Maeve Brennan, Truman Capote, Rachel Carson, John Cheever, Roald Dahl, Mavis Gallant, Geoffrey Hellman, Ernest Hemingway, Stephen King, Ruth McKenney, John McNulty, Joseph Mitchell, Alice Munro, Haruki Murakami, Vladimir Nabokov, John O'Hara, Dorothy Parker, S.J. Perelman, Philip Roth, George Saunders, J. D. Salinger, Irwin Shaw, James Thurber, John Updike, Eudora Welty, and E. B. White. Publication of Shirley Jackson's "The Lottery" drew more mail than any other story in the magazine's history. In its early decades, the magazine sometimes published two or even three short stories in an issue, but in later years the pace has remained steady at one story per issue.

The nonfiction feature articles (usually the bulk of an issue) cover an eclectic array of topics. Subjects have included eccentric evangelist Creflo Dollar, the different ways in which humans perceive the passage of time, and Münchausen syndrome by proxy.

The magazine is known for its editorial traditions. Under the rubric Profiles, it has published articles about prominent people such as Ernest Hemingway, Henry R. Luce and Marlon Brando, Hollywood restaurateur Michael Romanoff, magician Ricky Jay, and mathematicians David and Gregory Chudnovsky. Other enduring features have been "Goings on About Town", a listing of cultural and entertainment events in New York, and "The Talk of the Town", a feuilleton or miscellany of brief pieces—frequently humorous, whimsical, or eccentric vignettes of life in New York—in a breezily light style, although latterly the section often begins with a serious commentary. For many years, newspaper snippets containing amusing errors, unintended meanings or badly mixed metaphors ("Block That Metaphor") have been used as filler items, accompanied by a witty retort. There is no masthead listing the editors and staff. Despite some changes, the magazine has kept much of its traditional appearance over the decades in typography, layout, covers and artwork. The magazine was acquired by Advance Publications, the media company owned by Samuel Irving Newhouse Jr, in 1985, for $200 million when it was earning less than $6 million a year.

Ross was succeeded as editor by William Shawn (1951–87), followed by Robert Gottlieb (1987–92) and Tina Brown (1992–98). The current editor of The New Yorker is David Remnick, who succeeded Brown in July 1998.

Among the important nonfiction authors who began writing for the magazine during Shawn's editorship were Dwight Macdonald, Kenneth Tynan, and Hannah Arendt, whose Eichmann in Jerusalem reportage appeared in the magazine, before it was published as a book.

Brown's tenure attracted more controversy than Gottlieb's or even Shawn's, thanks to her high profile (Shawn, by contrast, had been an extremely shy, introverted figure), and to the changes she made to a magazine with a similar look for the previous half-century. She introduced color to the editorial pages (several years before The New York Times) and included photography, with less type on each page and a generally more modern layout. More substantively, she increased the coverage of current events and topics such as celebrities and business tycoons, and placed short pieces throughout "Goings on About Town", including a racy column about nightlife in Manhattan. A letters-to-the-editor page was introduced, and authors' bylines were added to their "Talk of the Town" pieces.

Since the late 1990s, The New Yorker has used the Internet to publish current and archived material, and maintains a website with some content from the current issue (plus exclusive web-only content). Subscribers have access to the full current issue online and a complete archive of back issues viewable as they were originally printed. In addition, The New Yorker's cartoons are available for purchase online. A digital archive of back issues from 1925 to April 2008 (representing more than 4,000 issues and half a million pages) was also issued on DVD-ROMs and on a small portable hard drive. More recently, an iPad version of the current issue has been released.  In 2014, The New Yorker opened up access online to all of its archives, expanded its plans to run an ambitious Website, and launched a paywalled subscription model. “What we’re trying to do,” said Nicholas Thompson, the editor of the Website, “is to make a website that is to the Internet what the magazine is to all other magazines.”

The magazine's editorial staff unionized in 2018 and The New Yorker Union signed its first collective bargaining agreement in 2021.

The New Yorker influenced a number of similar magazines, including The Brooklynite (1926 to 1930), The Chicagoan (1926 to 1935), and Paris's The Boulevardier (1927 to 1932).

Cartoons - COMIC ART

The New Yorker has featured cartoons (usually gag cartoons) since it began publication in 1925. For years, its cartoon editor was Lee Lorenz, who first began cartooning in 1956 and became a New Yorker contract contributor in 1958. After serving as the magazine's art editor from 1973 to 1993 (when he was replaced by Françoise Mouly), he continued in the position of cartoon editor until 1998. His book The Art of the New Yorker: 1925–1995 (Knopf, 1995) was the first comprehensive survey of all aspects of the magazine's graphics. In 1998, Robert Mankoff took over as cartoon editor and edited at least 14 collections of New Yorker cartoons. Mankoff also usually contributed a short article to each book, describing some aspect of the cartooning process or the methods used to select cartoons for the magazine. He left the magazine in 2017.

The New Yorker's stable of cartoonists has included many important talents in American humor, including Charles Addams, Peter Arno, Charles Barsotti, George Booth, Roz Chast, Tom Cheney, Sam Cobean, Leo Cullum, Richard Decker, Pia Guerra, J. B. Handelsman, Helen E. Hokinson, Pete Holmes, Ed Koren, Reginald Marsh, Mary Petty, George Price, Charles Saxon, Burr Shafer, Otto Soglow, William Steig, Saul Steinberg, James Stevenson, James Thurber, and Gahan Wilson.

Many early New Yorker cartoonists did not caption their cartoons. In his book The Years with Ross, Thurber describes the newspaper's weekly art meeting, where cartoons submitted over the previous week were brought up from the mail room to be looked over by Ross, the editorial department, and a number of staff writers. Cartoons were often rejected or sent back to artists with requested amendments, while others were accepted and captions were written for them. Some artists hired their own writers; Helen Hokinson hired James Reid Parker in 1931. Brendan Gill relates in his book Here at The New Yorker that at one point in the early 1940s, the quality of the artwork submitted to the magazine seemed to improve. It later was found out that the office boy (a teenaged Truman Capote) had been acting as a volunteer art editor, dropping pieces he did not like down the far end of his desk.

Several of the magazine's cartoons have reached a higher plateau of fame. One 1928 cartoon drawn by Carl Rose and captioned by E. B. White shows a mother telling her daughter, "It's broccoli, dear." The daughter responds, "I say it's spinach and I say the hell with it." The phrase "I say it's spinach" entered the vernacular, and three years later, the Broadway musical Face the Music included Irving Berlin's song "I Say It's Spinach (And the Hell with It)". The catchphrase "back to the drawing board" originated with the 1941 Peter Arno cartoon showing an engineer walking away from a crashed plane, saying, "Well, back to the old drawing board."

The most reprinted is Peter Steiner's 1993 drawing of two dogs at a computer, with one saying, "On the Internet, nobody knows you're a dog". According to Mankoff, Steiner and the magazine have split more than $100,000 in fees paid for the licensing and reprinting of this single cartoon, with more than half going to Steiner.

Over seven decades, many hardcover compilations of New Yorker cartoons have been published, and in 2004, Mankoff edited The Complete Cartoons of The New Yorker, a 656-page collection with 2,004 of the magazine's best cartoons published during 80 years, plus a double CD set with all 68,647 cartoons ever published in the magazine. This features a search function allowing readers to search for cartoons by cartoonist's name or year of publication. The newer group of cartoonists in recent years includes Pat Byrnes, J. C. Duffy, Liana Finck, Emily Flake, Robert Leighton, Michael Maslin, Julia Suits, and P. C. Vey. Will McPhail cited his beginnings as "just ripping off Calvin and Hobbes, Bill Watterson, and doing little dot eyes." The notion that some New Yorker cartoons have punchlines so oblique as to be impenetrable became a subplot in the Seinfeld episode "The Cartoon", as well as a playful jab in The Simpsons episode "The Sweetest Apu".