In 2016, the United States Mint released a quarter honoring Harpers Ferry National Historical Park in West Virginia as part of the America the Beautiful Quarters Program. The Harpers Ferry quarter features a design depicting John Brown's Fort, the site of John Brown's historic raid in 1859, which played a pivotal role in the events leading up to the American Civil War. In the background, the confluence of the Potomac and Shenandoah rivers is illustrated. The design also includes the inscriptions "Harpers Ferry," "West Virginia," "2016," and "E Pluribus Unum."

Harpers Ferry, located at the border of West Virginia, Maryland, and Virginia, is known for its historical significance. It was the site of abolitionist John Brown's raid on the federal armory, an event that intensified the national debate over slavery. The quarter design captures the historical importance of Harpers Ferry in the lead-up to the Civil War and the confluence of the two rivers that make the town a picturesque and historically rich location.