De Keyser's Royal Hotel was a large hotel on the Victoria Embankment, at its junction with New Bridge Street (now the A201), Blackfriars, London. The location was formerly the site of Bridewell Palace.

The Royal Hotel was founded before 1845 by Constant de Keyser, an immigrant to England from Belgium. It was a high-end hotel, catering mainly to visitors from continental Europe. His son Polydore de Keyser ran the hotel from around 1856.