Average teenager Peter Parker is transformed into an extraordinary superhero after he is accidentally bitten by a radioactive spider. When his beloved uncle is savagely murdered during a robbery, young Peter vows to use his powers to avenge his death. Deeming himself "Spider-Man" he sets about ridding the streets of crime, bringing him into conflict with malevolent super-villain, the "Green Goblin."

In SPIDER-MAN 2, based on the classic Marvel Comics hero, Tobey Maguire returns as the mild-mannered Peter Parker, who is juggling the delicate balance of his dual life as college student and a superhuman crime fighter. Peter's life becomes even more complicated when he confronts a new nemesis, the brilliant Otto Octavius (Alfred Molina) who has been reincarnated as the maniacal and multi-tentacled "Doc Ock." When Doc Ock kidnaps MJ (Kirsten Dunst), Spider-Man must swing back into action as the adventure reaches new heights of unprecedented excitement.