In Mille Fiori, you take the role of glass manufacturers and traders who want to profit as much as they can from their role in the production of glass art.

The game board features different aspects of the glass production cycle: workshops where the glass is created, houses where it's installed, people who support your work, trade shops where it's sold, and the harbor where ships bring glass to faraway locations. You want to be present in all of these areas, preferably at just the right time to maximize your earnings. The game board features 110 spaces, with one card in the deck for each of those spaces

Each player plays their card in turn, beginning with the round's start player and typically placing a diamond-shaped token of your color in the location depicted on that card:

• In the workshops, you score 1 point for each of your tokens in a connected group with the newly placed token, doubling that score if you played on a pigment field.
  
  
• In the line of houses, you score the listed number of points, and if your token is preceded in the line by one or more tokens of your color, you score those previously played tokens again.
  
  
• In the people pyramids, you score 1, 3 or 6 points based on the height of your token, but you can place at higher levels only if the lower spaces are filled. Double your points if the card symbol matches the space your filled. Supporting tokens score again as higher tokens are placed.
  
  
• In the trade shops, four types of goods are present, and when you place a token, each token on that goods type scores for its owner points equal to the number of goods of that type now covered.
  
  
• In the harbor, you move your ship equal to the number on the played card, scoring points based on the space where you land, then place a token in one of the five rows. When that row is filled with three ships, each token in that row scores for its owner 1/3/6/10 points depending on the number of trade goods in that row.