The Columbus Avenue site was originally known as the Bal Tabarin, a nightclub that featured dancing to famous bands and a multi-act floor show including a line of showgirls. Restaurateur and businessman Bob Grison partnered with popular bandleader Tom Gerun (born Gerunovich) and Frank Martinelli, manager of a nightclub called the Roof Garden, to establish a nightclub in 1930. Gerunovich's orchestra had played at the Roof Garden (northwest corner of Broadway and Kearny streets) from 1928 to 1930 and made several 78 rpm records for the Brunswick label. During a nationwide tour in mid-1929 he anglicized his name to Gerun. In 1931, in anticipation of the repeal of Prohibition in the United States, architect Timothy L. Pflueger was contracted to create an elegant, sophisticated nightclub and cocktail bar. The bar itself was implemented in the Moderne style later called Art Deco. The stage design used Pflueger's patented indirect lighting hidden behind curved strips of decorative metal. The color coming from behind the façade could be changed smoothly from one hue to another. Two years later, with alcohol bans officially lifted nationwide, the Bal Tabarin was issued California's first new liquor license, and in 1934 Pflueger gave the nightclub a quick renovation. The popularity of the club netted for Pflueger a series of contracts to design cocktail lounges for prominent hotels in San Francisco, including the Cirque Room at the Fairmont Hotel (which survives in its entirety, though it is no longer in use as a bar) and the Mark Hopkins' Top of the Mark, the interior of which has been remodeled to the point where no trace of the original design remains.

In 1936, a 13-year-old Ann Miller took a job dancing at Bal Tabarin, by lying about her age[10] – local law required workers to be 18 in a restaurant that served alcohol. On a night when Miller was appearing alongside Sophie Tucker and Tony Martin, Lucille Ball and an RKO Pictures studio agent came to watch the show. Miller was signed to RKO shortly afterwards, – though some sources say this occurred at The Black Cat Club.

Owner Tom Gerun contracted for several more show runs with Sophie Tucker through the 1940s. The club put on two floor shows a night, one at 9 or 9:30 and one starting around midnight. Gerun took the show some 120 miles (190 km) south to Fort Ord to entertain U.S. Army troops for a special engagement in August 1941. Other bands taking part in the show were Carl Ravazza and his Palace Hotel Band, and Robert Nurok and his band from the Alcazar nightclub. Coming from the Bal Tabarin were Bob Saunders and his band, Señor Wences (a ventriloquist), singer-actress Gertrude Niesen, and the Duncan Sisters with their vaudeville act. After World War II started in earnest for the United States, Martinelli joked with a Billboard reporter that it was easy to get big-name stars to perform at his club, but asked "can you tell me where I can get one waiter and two dishwashers? Those are the rare birds these days." After the war, Gerun hosted NBC broadcasts of Ted Lewis and his band, announced by Bill Roddy, performed live from the nightclub's stage. This activity was not enough to keep the club solvent – in 1947 Billboard reported their doors shut for a time so that the owners could save money as they attempted to sign a major musical artist. Gerun and Martinelli also admitted they were seeking a buyer for the place.

Bimbo's 365

In November 1950, Gerun and Martinelli sold the property to Agustino "Bimbo" Giuntoli for a reported $100,000, the equivalent of $1,076,000 in current value. The arrangement allowed the former owners to operate through January 1951, giving Giuntoli the keys on February 1. Giuntoli planned to hold the 365 Club on 365 Market Street open until July 1, 1951, when renovations to the former Bal Tabarin were to be completed. The new location was to be named Bimbo's 365. Giuntoli expanded the kitchen and added another bar but kept the older Pflueger bar in its original place.

Giuntoli's new location was soon a success, with engagements by musical artists such as accordionist Dick Contino, Latin bandleader Xavier Cugat with Charo, singer and trumpeter Louis Prima, bandleader and trumpeter Ray Anthony, entertainer Joey Bishop, lounge music composer Esquivel and many more. Comedians such as Sid Caesar, Rodney Dangerfield and Totie Fields performed. Popular columnist Herb Caen commented favorably on the array of acts, writing "Bimbo's [has] jugglers, dance teams, stand-up comics, crooners, chantootsies, Stage Door Johns, a proper band in proper uniforms ... multi-course dinners, red sparkling burgundy in the silver bucket..." as well as magician/movie actor Channing Pollock. In the late 1960s, the club expanded from its lounge atmosphere to put artists such as Smokey Robinson and the Miracles, Marvin Gaye, Neil Diamond, Glen Campbell and The Fifth Dimension on the bill...............................................