The 46th Bomb Squadron is an inactive United States Air Force unit. It was last assigned to the 319th Operations Group at Grand Forks Air Force Base, North Dakota, where it was inactivated on 16 July 1994.

The squadron was first organized in the reserve in 1947 as the 46th Bombardment Squadron. It was not fully manned before it was mobilized in 1951 and its personnel used as fillers for other units. From May 1955 to November 1957 it served in the reserves as the 46th Fighter-Bomber Squadron, standing air defense alert at its home station, Memphis Municipal Airport, during 1956 and 1957. It was inactivated when the Air Force reserves converted to an all troop carrier command.

From 1963 through the end of the Cold War, the squadron stood nuclear alert. It also deployed aircraft and personnel to Southeast Asia during the Vietnam War.